ID：P11
Pathogenesis：Neuropeptides
Other Terms：The enteric nervous system; ubstance P; corticotropin-releasing hormone; neurotensin; vasoactive intestinal peptide; μ-opioid receptor agonists; galanin
Description：Morphological, histological and immunohistochemical abnormalities of the enteric nervous system have been long recognized in human IBD tissues and a variety of neuropeptides with immunomodulatory functions has been proposed to have a role in IBD pathogenesis, such as substance P, corticotropin-releasing hormone, neurotensin, vasoactive intestinal peptide, μ-opioid receptor agonists and galanin

Related Literature

Colonic vasoactive intestinal peptide nerves in inflammatory bowel disease.
📅 Publication Date: 2025-07-23
📖 Source: Gastroenterology
# PMID: 1551531
Vasoactive intestinal peptide is a neuropeptide with potent modulatory activity on intestinal immunity and may be implicated in the pathogenesis of inflammatory bowel disease (IBD…
Role of neuropeptides in inflammatory bowel disease
📅 Publication Date: 2007-03-09
📖 Source: Inflamm Bowel Dis
# PMID: 17343284
🔗 DOI: 10.1002/ibd.20129
Inflammatory bowel disease (IBD) is a chronic relapsing disorder involving a dysregulated host-microbiota interaction. IBD patients have been shown to possess an increased risk …
Gut/brain axis and the microbiota.
📅 Publication Date: 2025-07-23
📖 Source: The Journal of clinical investigation
# PMID: 25689247
Tremendous progress has been made in characterizing the bidirectional interactions between the central nervous system, the enteric nervous system, and the gastrointestinal tract. …
Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system.
📅 Publication Date: 2025-07-23
📖 Source: The Journal of clinical investigation
# PMID: 25729852
The enteric nervous system (ENS) consists of neurons and glial cells that differentiate from neural crest progenitors. During embryogenesis, development of the ENS is controlled b…