ID：P3
Pathogenesis：Gut microbiota factor
Other Terms：Gut microbiome; Intestinal microbiota; Microbiota factor; antibiotics
Description：Several of the organisms are known to reside at the inflamed mucosa with the potential to exacerbate inflammation and/or invade intestinal epithelial cells, including strains of Escherichia and Fusobacterium.Haemophilus and Veillonella, have recently been reported to contribute to oral dysbiosis in IBD patients.Another factor affecting the gut microbial composition is the use of antibiotics.

Related Literature

Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae.
📅 Publication Date: 2025-07-23
📖 Source: Cell host & microbe
# PMID: 18005726
While the normal microbiota has been implicated as a critical defense against invading pathogens, the impact of enteropathogenic infection and host inflammation on intestinal micr…
The immunopathogenesis of Crohn's disease: a three-stage model.
📅 Publication Date: 2025-07-23
📖 Source: Current opinion in immunology
# PMID: 19665880
The pathogenesis of Crohn's disease (CD) has remained an enigma for at least a century. There was considerable optimism that genetic linkage and genome-wide association (GWA) stud…
Crohn's disease: NOD2, autophagy and ER stress converge
📅 Publication Date: 2011-01-22
📖 Source: Gut
# PMID: 21252204
🔗 DOI: 10.1136/gut.2009.206466
Mucosal tolerance is believed to be partly mediated by regulatory T cells. Intestinal epithelial cells (IECs) may play an important role in the generation of such regulatory cel…
The treatment-naive microbiome in new-onset Crohn's disease
📅 Publication Date: 2014-03-18
📖 Source: Cell Host Microbe
# PMID: 24629344
🔗 DOI: 10.1016/j.chom.2014.02.005
OBJECTIVE: Congenital sodium diarrhoea (CSD) refers to a form of secretory diarrhoea with intrauterine onset and high faecal losses of sodium without congenital malformations. T…
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
📅 Publication Date: 2025-07-23
📖 Source: Cell
# PMID: 25619688
Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these…