ID：P4

Pathogenesis：Innate immune

Other Terms：neutrophils; monocytes; macrophages; DCs; nonimmune cells; epithelial; mesenchymal cells

Description：One of the earliest signs of intestinal inflammation is the infiltration of the gut mucosa and epithelium by polymorphonuclear leukocytes (neutrophils), which persist throughout the course of IBD as long as active inflammation is present. Neutrophils contribute to IBD pathogenesis through a variety of mechanisms that include impairment of epithelial barrier function, tissue destruction through oxidative and proteolytic damage, and the perpetuation of inflammation through the release of multiple inflammatory mediators