ID：P5
Pathogenesis：Adaptive immunity
Other Terms：Humoral immunity; Effector T cells; Natural killer; innate lymphoid cells; T-cell apoptosis
Description：A general activation of the humoral immune response is found in both Crohn's disease and ulcerative colitis, manifested by various alterations in immunoglobulin subclass production.TH cells are intrinsically plastic and adaptable to stimuli from the surrounding environment, a characteristic extremely relevant to IBD pathogenesis.

Related Literature

Antibody secretion by human intestinal mononuclear cells from normal controls and inflammatory bowel disease patients
📅 Publication Date: 1989-01-01
📖 Source: Immunol Invest
# PMID: 2731973
🔗 DOI: 10.3109/08820138909112255
Inflammatory bowel disease (IBD) is a chronic illness that causes inflammation of the gastrointestinal tract. Symptoms commonly include frequency, urgency and faecal leaking or …
Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls.
📅 Publication Date: 2025-07-23
📖 Source: Clinical and experimental immunology
# PMID: 3802572
Spontaneous IgG and IgG subclass secretion patterns by isolated intestinal mononuclear cells (MNC) from control and inflammatory bowel disease (IBD) specimens were examined. Intes…
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease.
📅 Publication Date: 2025-07-23
📖 Source: Gut
# PMID: 11788561
BACKGROUND AND AIMS: Treatment with infliximab induces remission in about 70% of patients with steroid refractory Crohn's disease. Because Crohn's disease is considered to be medi…
Increased expression of interleukin 17 in inflammatory bowel disease
📅 Publication Date: 2002-12-13
📖 Source: Gut
# PMID: 12477762
🔗 DOI: 10.1136/gut.52.1.65
BACKGROUND: Experimental evidences suggest an increased collagen deposition in inflammatory bowel diseases (IBD). In particular, large amounts of collagen type I, III and V have…
Cross-talk between RORgammat+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease.
📅 Publication Date: 2025-07-23
📖 Source: Inflammatory bowel diseases
# PMID: 24991784
BACKGROUND: Interleukin (IL)-22-producing RORgammat innate lymphoid cells (ILCs) play a pivotal role in intestinal immunity. Recent reports demonstrated that ILCs contribute to mu…