ID：P7

Pathogenesis：Epithelial cells

Other Terms：intestinal mucosal deteriorations; IEC; CD8+ T ; (PPAR)-γ

Description：IBD-associated IECs are impaired in their capacity of inducing CD8+ T suppressor cells, suggesting a possible defect in mucosal immunoregulation predisposing to IBD.epithelial insufficiencies of the mucosal block are followed by strong antigenic intrusion and stimulation of the local immune system with disturbance of the local immune homeostasis and the formation of immune complexes. The interactions of phagocytes with immune complexes cause the release of degrading lysosomal enzymes, which leads to continuous injury of the mucosal block and therefore to a perpetuation of the disease.