ID：P8
Pathogenesis：Intestinal permeability
Other Terms：mucous layer; NOD2; goblet cells; Paneth cells; barrier defect
Description：A link between intestinal permeability and IBD immunopathogenesis is intuitive, as a properly regulated intestinal mucosal barrier is essential to health and disease.Increased intestinal permeability has long been described in patients with active Crohn's disease, and is positively correlated with an increased risk of relapse. Thus, a barrier defect could be a primary causative step in IBD immunopathogenesis, as it is found not only in patients with Crohn's disease, but also in up to 10% of their first-degree relatives

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📅 Publication Date: 2025-07-23
📖 Source: Gastroenterology
# PMID: 6407889
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📅 Publication Date: 2025-07-23
📖 Source: Lancet (London, England)
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📅 Publication Date: 2025-07-23
📖 Source: Gastroenterology
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📅 Publication Date: 2025-07-23
📖 Source: Annals of the New York Academy of Sciences
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📅 Publication Date: 2025-07-23
📖 Source: Nature reviews. Immunology
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