ID：P9
Pathogenesis：Intestinal fibrosis
Other Terms：Mesenchymal cells; ECM; fibrosis; Intestinal injury and repair
Description：ntestinal fibrosis, due to the excessive deposition of extracellular matrix (ECM), constitutes a common complication of IBD leading to stricture formation and obstruction. Fibrosis in Crohn's disease is more pronounced and usually transmural2, but fibrosis also occurs in ulcerative colitis, in which ECM deposits in the superficial layers of the intestinal wall

Related Literature

Fibrogenesis in Crohn's disease.
📅 Publication Date: 2025-07-23
📖 Source: The American journal of gastroenterology
# PMID: 17156147
INTRODUCTION: Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedur…
Intestinal fibrosis in IBD--a dynamic, multifactorial process
📅 Publication Date: 2009-04-07
📖 Source: Nat Rev Gastroenterol Hepatol
# PMID: 19347014
🔗 DOI: 10.1038/nrgastro.2009.31
The etiology of inflammatory bowel disease (IBD) is not completely understood, thus current therapies have been empirical and directed at treating symptoms rather than addressin…
Mechanisms of fibrosis: therapeutic translation for fibrotic disease.
📅 Publication Date: 2025-07-23
📖 Source: Nature medicine
# PMID: 22772564
Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or scarring, is defined by the accumulation of excess extracellular matrix components. If highl…
Crohn's disease complicated by strictures: a systematic review
📅 Publication Date: 2013-04-30
📖 Source: Gut
# PMID: 23626373
🔗 DOI: 10.1136/gutjnl-2012-304353
OBJECTIVES: To evaluate gastroenterology outpatients' attitudes to the importance of diet and its relationship to their symptoms, as well as their expectations of dietary advice…
Fibrosis in ulcerative colitis: mechanisms, features, and consequences of a neglected problem.
📅 Publication Date: 2025-07-23
📖 Source: Inflammatory bowel diseases
# PMID: 24892966
Chronic intestinal inflammation and impaired tissue repair leading to intestinal fibrosis are a commonly observed complication in inflammatory bowel disease. This is particularly …