New therapeutic possibilities in inflammatory bowel disease
PMID: 11718522
Source: Eur J Surg Suppl
Publication date:
2001-11-23
Year:
2001
Abstract
This paper summarizes the results of searching for evidence of loci contributing to simulated quantitative traits which are associated with a common genetic disease using two multipoint identity by descent (IBD) sharing methods: MIM and MAPMAKER/SIBS. In brief, by varying the lod-score threshold from 1 to 3, we found that MIM and MAPMAKER/SIBS have similar power to detect linkage, but MAPMAKER/SIBS consistently produces a higher number of false positives.