We report the case of a 38-year-old woman with a 10-year history of ulcerative proctosigmoiditis. Two months after traveling to Morocco, she developed gastrointestinal symptoms accompanied by eosinophilia in blood tests. Four months later, she progressed to systemic illness with pulmonary involvement. A colonoscopy revealed aphthous ileitis with nonspecific histology suggestive of Crohn's Disease (CD). Ultimately, serology confirmed Strongyloides stercoralis infection. Strongyloidiasis is underdiagnosed in Spain, and its differentiation from CD presents a diagnostic challenge.