Introduction: In surgical departments where a sufficient number of thyroid surgeries are performed, relatively rare histopathological diagnoses may also be encountered. Knowledge of these histopathological diagnoses is essential for understanding the etiology and selecting the appropriate treatment for the disease. Objective: We aimed to determine the prevalence of amyloid goiter and to examine its associations with related conditions. Method: Between 2001 and 2023, we performed 2,215 thyroid surgeries. We conducted a retrospective review of the histopathological findings and correlated these results with the patients' medical histories. Result: Out of the 2,215 operated cases, amyloid goiter was diagnosed histopathologically in only 2 cases, accounting for just 0.09% of all cases. Discussion: Amyloid goiter typically appears in association with other conditions. In our cases, it was linked to chronic renal failure with prolonged dialysis treatment and inflammatory bowel disease (Crohn's disease). The surgical indication is based on the mechanical compression caused by the enlarged thyroid gland. Conclusion: In cases of diffuse goiter with compression symptoms of unknown origin, amyloid goiter should be considered. Total thyroidectomy resolves the patient's symptoms. However, the exact diagnosis is usually confirmed only through the histopathological examination of the surgical specimen. Orv Hetil. 2025; 166(15): 588-591.