A few studies have reported immunoglobulin A nephropathy (IgAN) complications in pediatric patients with Crohn disease (CD). Additionally, reports of severe atopic dermatitis (AD) complicating CD with IgAN are rare. In this case report, we review the case of a 10-year-old boy with CD later complicated by IgAN and severe AD at various time points. In his treatment course, he required multiple concurrent therapies, including upadacitinib and infliximab, to achieve remission for all 3 conditions. This case reports successful simultaneous treatment with separate agents in a pediatric case of CD complicated by severe AD.