Chronic diseases of the gastrointestinal tract or the liver manifest themselves in a significant number of patients as early as childhood or adolescence. The majority of these diseases require complex drug therapy and continuous care. This makes the transition to adult medicine all the more critical, as it is a challenging phase of life per se. This article will present examples from various gastroenterology and hepatology centers. Subsequently, position papers and guidelines from national and international specialist societies will be discussed. Finally, the Berlin Transition Program (Berliner TransitionsProgramm, BTP) will be presented as a possible model for gastroenterology.