γδT Cells in IBD: Beneficial or Detrimental?
Abstract
gammadeltaT cells play a crucial role in inflammatory bowel disease (IBD). Studies have shown that the number, subsets and secreted cytokines of gammadeltaT cells undergo changes in IBD. However, whether gammadeltaT cells are beneficial or detrimental in IBD remains controversial. Some studies suggest that gammadeltaT cells have a protective role in colitis, while others indicate that the expansion and activation of gammadeltaT cells may exacerbate colitis. Several studies have explored gammadeltaT cell-based therapies for immune disorders, and gammadeltaT cell-based therapy for IBD has emerged as a promising research direction. There are numerous reviews of gammadeltaT cells and autoimmune diseases, but few reviews focus on gammadeltaT and IBD. Therefore, this article briefly summarises the current understanding of gammadeltaT cells in IBD.