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Targeting Inflammation and Oxidative Stress to Improve Outcomes in a TNBS Murine Crohn's Colitis Model

Publication Year: 2024 Source: Nanomaterials (Basel) PMID: 38786849

No Abstract

Canine Mesenchymal Stromal Cell Exosomes: State-of-the-Art Characterization, Functional Analysis and Applications in Various Diseases

Publication Year: 2024 Source: Vet Sci PMID: 38787159

No Abstract

Therapeutic Applications of Aggregatibacter actinomycetemcomitans Leukotoxin

Publication Year: 2024 Source: Pathogens PMID: 38787206

No Abstract

Bone mineral density of the incus body and long process in patients with chronic otitis media and its relationship with functional outcome in type II tympanoplasty

Publication Year: 2024 Source: Acta Otolaryngol PMID: 38787327 DOI: 10.1080/00016489.2024.2356611

BACKGROUND: Inflammatory conditions such as chronic otitis media (COM) can cause irreversible impairments in the microarchitecture and functions of the incus, which subsequently leads to conductive hearing loss. OBJECTIVES: To investigate bone mineral density (BMD) of the incus body (IB) and long process (ILP) on preoperative temporal CT in COM …

Probiotics Armed with In Situ Mineralized Nanocatalysts and Targeted Biocoatings for Multipronged Treatment of Inflammatory Bowel Disease

Publication Year: 2024 Source: Nano Lett PMID: 38787330 DOI: 10.1021/acs.nanolett.4c01143

While oral probiotics show promise in treating inflammatory bowel disease, the primary challenge lies in sustaining their activity and retention within the inflamed gastrointestinal environment. In this work, we develop an engineered probiotic platform that is armed with biocatalytic and inflamed colon-targeting nanocoatings for multipronged management of IBD. Notably, we …

Association between inflammatory bowel disease and primary sclerosing cholangitis: Insights from bibliometric analysis

Publication Year: 2024 Source: Medicine (Baltimore) PMID: 38788011

No Abstract

Quantitative analysis of contrast-enhanced ultrasound and superb microvascular imaging for the evaluation of disease activity in inflammatory bowel disease

Publication Year: 2024 Source: Clin Hemorheol Microcirc PMID: 38788062 DOI: 10.3233/CH-242114

OBJECTIVE: To evaluate the effectiveness of conventional US (ultrasound), SMI (superb microvascular imaging), and CEUS (contrast-enhanced ultrasound) features for the assessment of the activity of inflammatory bowel disease. METHODS: Conventional US, CEUS and SMI features of 76 patients were retrospectively analyzed. Patients were categorized into two groups: active group (n …

Enterococcus-derived tyramine hijacks α(2A)-adrenergic receptor in intestinal stem cells to exacerbate colitis

Publication Year: 2024 Source: Cell Host Microbe PMID: 38788722 DOI: 10.1016/j.chom.2024.04.020

Inflammatory bowel disease (IBD) is characterized by dysbiosis of the gut microbiota and dysfunction of intestinal stem cells (ISCs). However, the direct interactions between IBD microbial factors and ISCs are undescribed. Here, we identify alpha(2A)-adrenergic receptor (ADRA2A) as a highly expressed GPCR in ISCs. Through PRESTO-Tango screening, we demonstrate that …

Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients

Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38788739 DOI: 10.1093/ibd/izae109

BACKGROUND: Patients with inflammatory bowel disease (IBD) exhibit considerable interindividual variability in medication response, highlighting the need for precision medicine approaches to optimize and tailor treatment. Pharmacogenetics (PGx) offers the ability to individualize dosing by examining genetic factors underlying the metabolism of medications such as thiopurines. Pharmacogenetic testing can identify …

N-ethyl-N-nitrosourea (ENU)-induced C-terminal truncation of Runx3 results in autoimmune colitis associated with Th17/Treg imbalance

Publication Year: 2024 Source: Immunol Lett PMID: 38788802 DOI: 10.1016/j.imlet.2024.106869

Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory intestinal disease that affects people around the world. The primary cause of IBD is an imbalance in the host immune response to intestinal flora. Several human genes, including IL10, STAT3, IRGM, ATG16L1, NOD2 and RUNX3, are associated with inappropriate immune …

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