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Discovery of GPR84 Fluorogenic Probes Based on a Novel Antagonist for GPR84 Bioimaging
Publication Year: 2024 Source: J Med Chem PMID: 38946306
No Abstract
Greater adherence to the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with lower risk of inflammatory bowel disease: a prospective cohort study
Publication Year: 2024 Source: Food Funct PMID: 38946529 DOI: 10.1039/d4fo00641k
Background: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is emerging as a promising candidate for preventive measures against inflammatory bowel disease (IBD), though there is currently no direct evidence from population-based studies. This study aims to bridge the gap in understanding of the association of the MIND diet with …
Clinical impacts of immunomodulator withdrawal from anti-tumor necrosis factor combination therapy in pediatric inflammatory bowel disease
Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38946674 DOI: 10.1002/jpn3.12299
OBJECTIVES: Combination therapy consists of both anti-tumor necrosis factor (anti-TNF) and an immunomodulator (IMM) and has been shown to improve outcomes in patients with inflammatory bowel disease (IBD). This study assesses the impacts of IMM withdrawal from combination therapy to anti-TNF monotherapy in children with IBD. METHODS: This single-center retrospective …
Liver enzyme profiles after initiating biological treatment in children with inflammatory bowel diseases
Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38946705
No Abstract
Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis
Publication Year: 2024 Source: Precis Clin Med PMID: 38946731
No Abstract
From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders
Publication Year: 2024 Source: World J Gastroenterol PMID: 38946875
No Abstract
Interaction between inflammatory bowel disease, physical activity, and myokines: Assessment of serum irisin levels
Publication Year: 2024 Source: World J Gastroenterol PMID: 38947287 DOI: 10.3748/wjg.v30.i22.2923
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, showed a wide spectrum of intestinal and extra-intestinal manifestations, which rendered the patients physically inactive and impaired their quality of life. It has been found that physical activity is a non-pharmacological intervention that improves the quality of life for those …
Approach to loss of response to advanced therapies in inflammatory bowel disease
Publication Year: 2024 Source: World J Gastroenterol PMID: 38947290
No Abstract
Organoids as regenerative medicine for inflammatory bowel disease
Publication Year: 2024 Source: iScience PMID: 38947526 DOI: 10.1016/j.isci.2024.110118
Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global prevalence. Managing disease activity relies on various pharmacological options. However, the effectiveness of current therapeutics is limited and not universally applicable to all patients and circumstances. Consequently, developing new management strategies is necessary. Recent advances in endoscopically obtained …
Endoscopy of Low BMI Patients Compared to Normal BMI Patients: A Study From the Aseer Region, Saudi Arabia
Publication Year: 2024 Source: Cureus PMID: 38947624 DOI: 10.7759/cureus.61276
Gastrointestinal (GI) endoscopies are essential for detecting and treating various digestive tract problems. While typically safe, these treatments can entail the risk of severe adverse events (SAEs), especially in individuals with a low body mass index (BMI). The current study aimed to evaluate whether post-endoscopy SAEs are more common in …
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