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Luteolin Modulate Endoplasmic Reticulum Stress by Targeting SIRT1 to Ameliorate DSS-Induced Ulcerative Colitis in Mice
Publication Year: 2025 Source: FASEB J PMID: 40205885
Ulcerative colitis (UC) is a recurrent, chronic disease whose main symptoms include weight loss, diarrhea, and blood in the stool. In recent years, the incidence of UC has been increasing year by year, which seriously affects the daily life of patients. Luteolin (Lut), as a flavonoid, is widely found in …
Effectiveness and safety of rectal tacrolimus in patients with ulcerative colitis. TACRO-TOPIC study of GETECCU
Publication Year: 2025 Source: J Crohns Colitis PMID: 40205922
INTRODUCTION: Data about the efficacy of topical therapy with tacrolimus in patients with ulcerative colitis (UC) are scarce. Therefore, this study aimed to evaluate topical tacrolimus's (TT) effectiveness and adverse events in a real-world setting. METHODS: A multicenter retrospective study was conducted at 27 hospitals across Spain. Adult patients with …
Proactive pharmacogenomics in azathioprine-treated pediatric inflammatory bowel disease at a Chinese tertiary hospital
Publication Year: 2025 Source: Front Pharmacol PMID: 40206080 DOI: 10.3389/fphar.2025.1558897
BACKGROUND: Despite the emergence of numerous innovative targeted therapies for the management of pediatric inflammatory bowel disease (IBD), azathioprine continues to be a pivotal first-line therapeutic agent. Nonetheless, the considerable frequency of myelosuppression associated with its use warrants careful consideration and further investigation. This study aims to investigate the application …
Dexamethasone-Induced MerTK(+/high) M2c Macrophages Exhibit a Preference for Downregulated Gene Expression Profiles
Publication Year: 2025 Source: J Genomics PMID: 40206211
In a prior study, adoptive cell transfer (ACT) of Dexamethasone (DEX)-induced M2c macrophages with positive expression of MerTK receptor mitigated acute allograft rejection, which was observed in the presence of apoptotic lymphocytes, while simultaneously reducing MHC-II and CD8(+) T cells in the recipients. However, there has been limited exploration of …
Editorial: Gastrointestinal (GI) disorders and antioxidant therapeutics
Publication Year: 2025 Source: Front Endocrinol (Lausanne) PMID: 40206596
No Abstract
Symphony of the gut microbiota and endocannabinoidome: a molecular and functional perspective
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40207053 DOI: 10.3389/fcimb.2025.1566290
This review examines the impact of interactions between the gut microbiota and the endocannabinoidome (eCBome) on health and disease, highlighting their significance for physiological and pathological processes. We identify key research gaps and challenges to advance the field. The review discusses the role of dietary patterns and physical activity in …
Temporal Trends in Surgery and Hospitalization Rates for Crohn's Disease in Brazil: A Population-Based Study
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40207073
INTRODUCTION: Biological therapy has transformed the natural course of inflammatory bowel disease, but there are still controversies regarding its potential to reduce surgical rates for Crohn's disease (CD). This study, conducted with the support of the Brazilian National Healthcare System, aimed to analyze temporal trends in surgery and hospitalization rates …
Unveiling the fungal frontier: mycological insights into inflammatory bowel disease
Publication Year: 2025 Source: Front Immunol PMID: 40207229 DOI: 10.3389/fimmu.2025.1551289
Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal disease that seriously affects the quality of life of patients around the world. It is characterized by recurrent abdominal pain, diarrhea, and mucous bloody stools. There is an urgent need for more accurate diagnosis and effective treatment of IBD. Accumulated evidence …
Ultrasound for detection of complications and evaluation of treatment response in inflammatory bowel disease (IBD)?
Publication Year: 2025 Source: Med Ultrason PMID: 40207395 DOI: 10.11152/mu-4493
Ultrasound (US) can be performed at the point of care by the treating physician, is safe, well tolerated and, therefore, can be repeated as often as clinically required and shortens the time to decision. An invaluable advantage of US is that the imaging is real-time and pathophysiological phenomena can be …
A comparison between the Bowel Ultrasound Score and International Bowel Ultrasound Segmental Activity Score based on ileocolonoscopy in patients with Crohn's disease
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 40207494
BACKGROUND AND AIM: We aimed to compare two main existing scores, the Bowel Ultrasound Score (BUSS) and the International Bowel Ultrasound Segmental Activity Score (IBUS-SAS) to predict simplified endoscopic activity score for Crohn's disease (SES-CD). METHODS: A cross-sectional study was conducted to evaluate the disease activity in Crohn's disease (CD) …
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