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The Bidirectional Effects of Periodontal Disease and Oral Dysbiosis on Gut Inflammation in Inflammatory Bowel Disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39447062 DOI: 10.1093/ecco-jcc/jjae162
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) flares can lead to excessive morbidity and mortality. This study aimed to determine whether oral dysbiosis/periodontal disease (PD) is common in IBD and is associated with disease activity in IBD. METHODS: This single-center, prospective, cross-sectional, proof-of-concept, and observational study assessed the frequency of …
Rectal mass: Cancer or endometriosis?
Publication Year: 2025 Source: Gastrointest Endosc PMID: 39447989
No Abstract
Butyrolactone-I from marine fungi alleviates intestinal barrier damage caused by DSS through regulating lactobacillus johnsonii and its metabolites in the intestine of mice
Publication Year: 2025 Source: J Nutr Biochem PMID: 39447992 DOI: 10.1016/j.jnutbio.2024.109786
Butyrolactone-I (BTL-1), a secondary metabolite from the marine fungus Aspergillus terreus, exhibits numerous biological activities. Previous research has indicated that Butyrolactone-I alleviates intestinal epithelial inflammation via the TLR4/NF-kappaB and MAPK pathways. However, the mechanisms underlying its protection against intestinal barrier damage remain unclear. This study aims to further elucidate these …
Three-Year Efficacy and Safety of Mirikizumab Following 152 Weeks of Continuous Treatment for Ulcerative Colitis: Results From the LUCENT-3 Open-Label Extension Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39448057
BACKGROUND: Mirikizumab, a p19-directed interleukin-23 monoclonal antibody, has demonstrated induction of clinical remission at week 12 with maintenance through week 104 in patients with moderately-to-severely active ulcerative colitis (UC). Results are presented from the LUCENT-3 open-label extension study through week 152. METHODS: Of 868 LUCENT clinical trial program mirikizumab-treated induction …
cGAS-STING DNA-sensing in inflammatory bowel diseases
Publication Year: 2025 Source: Trends Mol Med PMID: 39448330 DOI: 10.1016/j.molmed.2024.10.002
Inflammatory bowel diseases (IBD) are chronic, incurable pathologies with unknown causes, affecting millions of people. Pediatric-onset IBD, starting before the age of 18 years, are increasing, with more aggressive and extensive features than adult-onset IBD. These differences remain largely unexplained. Intestinal mucosal damage, cell death, DNA release from nuclear, mitochondrial, …
Host-pathobiont interactions in Crohn's disease
Publication Year: 2025 Source: Nat Rev Gastroenterol Hepatol PMID: 39448837
No Abstract
Early-Life Infections, Antibiotics and Later Risk of Childhood and Early Adult-Onset Inflammatory Bowel Disease: Pooled Analysis of Two Scandinavian Birth Cohorts
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39450871 DOI: 10.1111/apt.18358
BACKGROUND: Childhood antibiotic use has been associated with inflammatory bowel disease (IBD), although the potential contribution of infection frequency remains uncertain. AIMS: To explore the association between early-life infections, antibiotics and IBD development. METHODS: We used population-based data from ABIS (Sweden) and MoBa (Norway) cohorts following children from birth (1997-2009) …
How Do Men Who Post Publicly on Social Media Author Themselves and Their Experiences of Crohn's Disease? A Dialogical Analysis of Three Cases
Publication Year: 2025 Source: Qual Health Res PMID: 39450937
No Abstract
Kidney Failure, Inflammatory Bowel Disease, and Colectomy
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39454978
No Abstract
The Future of Inflammatory Bowel Disease Care
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39454983
No Abstract
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