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Establishment of a 3D multi-layered in vitro model of inflammatory bowel disease
Publication Year: 2025 Source: J Control Release PMID: 39617170 DOI: 10.1016/j.jconrel.2024.11.070
Crohn's Disease and Ulcerative Colitis, the main types of Inflammatory Bowel Disease (IBD), are life-threatening gastrointestinal disorders with no definitive cure. The establishment of biorelevant in vitro models that closely recapitulate the IBD microenvironment is of utmost importance to validate newly developed IBD therapies. To address the existing flaws in …
PET biodistribution study of subcutaneous and intravenous administration of adalimumab in an inflammatory bowel disease model
Publication Year: 2025 Source: Int J Pharm PMID: 39617190 DOI: 10.1016/j.ijpharm.2024.125011
Monoclonal antibodies targeting tumor necrosis factor-alpha (antiTNF-alpha) are used for patients with immuno-mediated illness as inflammatory bowel disease (IBD). However, 20-40 % of IBD patients do not respond to these therapies, and increasing knowledge of biodistribution could optimize their use and consequently their effectiveness. The aim of this study is …
Development of mesalamine loaded-fenugreek gum decorated pectin microspheres for colonic drug delivery: Ex-vivo and in-vitro characterizations
Publication Year: 2025 Source: Ann Pharm Fr PMID: 39617337 DOI: 10.1016/j.pharma.2024.11.006
Mesalamine (MES) is a preferred therapeutic agent for managing various colon disorders, including inflammatory bowel diseases (IBD). However, conventional oral dosage forms of MES face significant limitations, which reduce their effectiveness in managing these conditions. To overcome these challenges, advanced dosage forms of MES are essential. Fenugreek gum (FG), a …
Hyperinfestation by Strongyloides stercolaris in an immunodepressed patient due to inflammatory bowel disease
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39617338
No Abstract
Italian validation of the IBD-disk tool for the assessment of disability in inflammatory bowel diseases: A cross-sectional multicenter study
Publication Year: 2025 Source: Dig Liver Dis PMID: 39617658 DOI: 10.1016/j.dld.2024.11.004
INTRODUCTION: IBD-Disk is a simple, easy-to-use, and self-administered analogue visual tool for assessing disability in patients with Inflammatory Bowel Disease (IBD). However, it has not yet been validated in Italian. This study aims to validate IBD-Disk in an Italian cross-sectional multicentre study. METHODS: This study was conducted in eight IBD …
Patients with functional gastrointestinal disorders spend less time in tertiary care when managed by a single clinician: results of a multicentre audit in South Australia
Publication Year: 2025 Source: Intern Med J PMID: 39620659
No Abstract
One Concentration Does Not Fit All: It Is Time to Personalize the Therapeutic Range of Infliximab in Crohn Disease
Publication Year: 2025 Source: Ther Drug Monit PMID: 39621838
No Abstract
The incidence of hepatitis B reactivation in patients receiving ustekinumab: a systematic review and proportional meta-analysis
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39621878
No Abstract
Sarcopenia is associated with worse outcomes in patients with inflammatory bowel disease: insights from US national hospitalization data
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39621879 DOI: 10.1097/MEG.0000000000002852
BACKGROUND: Inflammatory bowel disease (IBD) is an inflammatory disorder associated with significant morbidity and mortality. Recent studies have reported sarcopenia as a significant factor affecting the quality of life and outcomes of these patients. METHODS: We used the National Inpatient Sample 2016-2020 to identify adult patients with IBD. The patients …
Effects of Centella asiatica-isolated pectic polysaccharide on dextran sulfate sodium-induced colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39622374 DOI: 10.1016/j.ijbiomac.2024.138237
Dietary supplementation of polysaccharides demonstrates strong therapeutic actions on inflammatory bowel disease (IBD). Centella asiatica (CA) has traditionally been used in Ayurveda and Chinese medicine. However, the effects of CA-isolated pectic polysaccharides on IBD remain unknown. This study determined the effect of a CA-isolated pectic polysaccharide on IBD. The crude …
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