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Eosinophil Depletion as a Potential Therapeutic Strategy in Acute and Chronic Intestinal Inflammation Based on a Dextran Sulfate Sodium Colitis Model
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39107256
BACKGROUND: A role for eosinophils in intestinal inflammation and fibrosis in the context of inflammatory bowel disease has been suggested, yet the precise nature, whether causal or secondary remains debated. Hence, it remains unclear whether targeting eosinophils should be further explored as a treatment option in inflammatory bowel disease. METHODS: …
Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain
Publication Year: 2025 Source: Arthritis Rheumatol PMID: 39107875 DOI: 10.1002/art.42967
OBJECTIVE: We aimed to assess the following: (1) the frequency of axial spondyloarthritis (axSpA) according to extra-articular presentation and HLA-B27 status, (2) clinical and imaging features that distinguish axSpA from non-axSpA, and (3) the impact of magnetic resonance imaging (MRI) on diagnosis and classification of axSpA. METHODS: The Screening for …
The Costs of Home Monitoring by Telemedicine vs Standard Care for Inflammatory Bowel Diseases-A Danish Register-Based, 5-Year Follow-up Study
Publication Year: 2025 Source: J Crohns Colitis PMID: 39110131 DOI: 10.1093/ecco-jcc/jjae120
BACKGROUND AND AIMS: There are few studies on the cost-effectiveness of telemedicine for inflammatory bowel diseases. We assessed the long-term cost-effectiveness of a telemedicine solution compared to standard care (sCare), as well as its efficacy according to patient-reported outcomes (PROs). METHODS: Between 2015 and 2020, we conducted a retrospective, register-based …
Assessing the Value of Histology and Anatomic Segment Evaluation Among Patients Undergoing Pouchoscopy
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39110503
BACKGROUND: The value of histologic assessment after ileal pouch-anal anastomosis (IPAA) has not been definitively determined. We evaluated the correlation between histology and endoscopic findings, as well as the proportion of patients with inflammation in areas beyond the pouch body on their initial pouchoscopy after IPAA. METHODS: In a retrospective …
Distribution of Serum Testosterone Concentrations in IBD Males and Associations With Inflammatory Bowel Disease Activity
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39110886 DOI: 10.1093/ibd/izae177
BACKGROUND: An inverse relationship exists between inflammation and testosterone concentrations in non-inflammatory bowel disease (IBD) immune conditions but has not been objectively explored in the IBD male population. We aimed to characterize the distribution of testosterone concentrations in a cohort of males with IBD and identify any relationship between testosterone …
Small bowel Crohn's disease: Proximal lesions linked to increased inflammation and biologic treatment needs
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39111390
No Abstract
Anti-Cytokine Active Immunotherapy Based on Supramolecular Peptides for Alleviating IL-1β-Mediated Inflammation
Publication Year: 2025 Source: Adv Healthc Mater PMID: 39113323
No Abstract
Fecal Calprotectin Diagnostic Level Gradient Along the Small Bowel in Patients With Crohn's Disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39120437 DOI: 10.1093/ecco-jcc/jjae123
BACKGROUND AND AIMS: Fecal calprotectin (FC) is known to be a sensitive biomarker of colonic inflammation but to a lesser degree of small bowel (SB) inflammation. Moreover, data on FC's diagnostic levels in different SB segments are scarce. We aimed to examine FC's diagnostic levels along the SB axis in …
Sodium orthovanadate protects against ulcerative colitis and associated liver damage in mice: insights into modulations of Nrf2/Keap1 and NF-κB pathways
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 39120720
No Abstract
Zein: Potential biopolymer in inflammatory bowel diseases
Publication Year: 2025 Source: J Biomed Mater Res A PMID: 39210660 DOI: 10.1002/jbm.a.37785
Effectively managing inflammatory bowel disease (IBD) poses difficulties due to its persistent nature and unpredictable episodes of exacerbation. There is encouraging evidence that personalized medication delivery systems can improve therapy efficacy while reducing the negative effects of standard medicines. Zein, a protein produced from corn, has garnered interest as a …
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