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Diagnosis and Management of Clostridioides difficile in Inflammatory Bowel Disease
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39230037 DOI: 10.14309/ajg.0000000000003076
Patients with inflammatory bowel disease (IBD) have an increased risk of Clostridioides difficile infection (CDI), which can lead to worse IBD outcomes. The diagnosis of CDI in patients with IBD is complicated by higher C. difficile colonization rates and shared clinical symptoms of intestinal inflammation. Traditional risk factors for CDI, …
Umbelliprenin attenuates comorbid behavioral disorders in acetic acid-induced colitis in mice: mechanistic insights into hippocampal oxidative stress and neuroinflammation
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 39230587 DOI: 10.1007/s00210-024-03416-w
Inflammatory bowel disease (IBD) is often accompanied by psychiatric disorders. Emerging evidence suggests that neuroinflammation and oxidative stress contribute to the psychiatric symptoms associated with IBD. Umbelliprenin (UMB) possesses several pharmacological properties, including anti-inflammatory and antioxidant effects. This study aimed to investigate the protective effects of UMB on comorbid behavioral …
Induction of Endoscopic Response, Remission, and Ulcer-Free Endoscopy With Upadacitinib Is Associated With Improved Clinical Outcomes and Quality of Life in Patients With Crohn's Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39231444
BACKGROUND: We evaluated the association of achieving endoscopic outcomes at week 12 of induction with improvements in clinical outcomes and quality of life (QoL) at week 52 of maintenance in patients with moderately to severely active Crohn's disease (CD) treated with upadacitinib (UPA). METHODS: This post hoc analysis evaluated data …
Immediate Hypersensitivity Reactions to Biologic Drugs in Children with Inflammatory Bowel Diseases
Publication Year: 2025 Source: Int Arch Allergy Immunol PMID: 39231451 DOI: 10.1159/000540795
INTRODUCTION: The increased use of biologic drugs (BDs) may lead to an increase in immediate hypersensitivity reactions (I-HSRs) in pediatric patients with inflammatory bowel disease (IBD). Our aim was to assess I-HSRs to BDs in pediatric IBD, examining frequency, clinical features, management, and associated risk factors. METHODS: All children diagnosed …
Factors influencing food-related quality of life in patients with inflammatory bowel disease: A systematic review
Publication Year: 2025 Source: J Eval Clin Pract PMID: 39234630 DOI: 10.1111/jep.14133
BACKGROUND: People diagnosed with Inflammatory bowel disease (IBD) often have severe dietary restrictions and avoidance due to the uncertainty of intestinal symptoms. Inadequate dietary intake may increase the risk of malnutrition and result in impaired food-related quality of life (FRQoL). Few studies investigated factors influencing FRQoL in patients with IBD. …
Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease
Publication Year: 2025 Source: Adv Healthc Mater PMID: 39235381 DOI: 10.1002/adhm.202401994
Ceria-based nanoparticles are versatile in treating various inflammatory diseases, but their feasibility in clinical translation is undermined by safety concerns and a limited delivery system. Meanwhile, the idiopathic nature of inflammatory bowel disease (IBD) calls for a wider variety of therapeutics via moderation of the intestinal immune system. In this …
Clinical efficacy and future application of indigo naturalis in the treatment of ulcerative colitis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39236777
No Abstract
Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn's Disease
Publication Year: 2025 Source: Gastroenterology PMID: 39236898
No Abstract
CT-based body composition parameters predict the loss of response to infliximab in patients with Crohn's disease
Publication Year: 2025 Source: Am J Med Sci PMID: 39237035
No Abstract
Conservative Lymph Node Sampling Is Clinically Appropriate in Intestinal Resections Related to Nonneoplastic Inflammatory Bowel Disease: A Single Institution Experience
Publication Year: 2025 Source: Arch Pathol Lab Med PMID: 39237110 DOI: 10.5858/arpa.2024-0184-OA
CONTEXT.-: In this era of health care challenges, efficient resource use is crucial. Patients with inflammatory bowel disease (IBD) may undergo surgery owing to treatment-refractory disease or strictures. Unlike colorectal cancer resections, there are no guidelines for lymph node retrieval in nonmalignant IBD resections. OBJECTIVE.-: To assess the usefulness and …
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