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All you need to know about the overlap between primary sclerosing cholangitis and inflammatory bowel disease
Publication Year: 2025 Source: Ann Gastroenterol PMID: 40124424 DOI: 10.20524/aog.2025.0945
Primary sclerosing cholangitis (PSC) is a progressive auto-inflammatory condition of the biliary ducts clinically characterized by painless cholestasis and jaundice. Histologically, the typical findings in PSC are periductal fibrosis with inflammation, bile duct proliferation, and ductopenia. These hallmarks eventually develop into end-stage liver disease requiring liver transplantation (LT), although the …
Age of onset of inflammatory bowel disease is the strongest risk factor for the development of malignancy
Publication Year: 2025 Source: Ann Gastroenterol PMID: 40124429 DOI: 10.20524/aog.2025.0952
BACKGROUND: Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a multifactorial inflammatory disorder of the gastrointestinal system that impairs the patient's quality of life. Its presentation includes a spectrum of symptoms that may also be secondary to IBD complications, such as malignancy. On the other hand, …
A rare paediatric case with overlapping clinical features of epidermodysplasia verruciformis and pyoderma gangrenosum with hepatosplenomegaly
Publication Year: 2025 Source: Skin Health Dis PMID: 40125015
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that typically manifests as painful ulcers, usually on the lower limbs, and is usually secondary to other conditions, for example inflammatory bowel disease and rheumatoid arthritis. Epidermodysplasia verruciformis (EDV) is an inherited or acquired primary immunodeficiency disorder linked to human papillomavirus susceptibility …
Inflammatory Bowel Disease and Stroke: Exploring Hidden Vascular Risks
Publication Year: 2025 Source: Cureus PMID: 40125129 DOI: 10.7759/cureus.79304
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is primarily known for its gastrointestinal manifestations. However, emerging evidence suggests a potential link between IBD and an increased risk of stroke, likely mediated by chronic systemic inflammation, endothelial dysfunction, and a prothrombotic state. Despite this growing recognition, the exact …
Challenges and limitations in assessing mucosal healing in Crohn's disease: Discrepancies between endoscopic and histologic evaluations
Publication Year: 2025 Source: World J Gastrointest Endosc PMID: 40125502
The recent study published by Lee et al examined the discrepancies between endoscopic and histologic evaluations of mucosal inflammation in active ileal Crohn's disease (CD). While this research contributes to our understanding of the limitations of current biopsy protocols, it raises several concerns about the generalizability of its findings, sample …
Non-invasive monitoring of inflammatory bowel disease using intestinal ultrasound
Publication Year: 2025 Source: World J Gastrointest Endosc PMID: 40125503 DOI: 10.4253/wjge.v17.i3.97016
BACKGROUND: Intestinal ultrasound (IUS) is a safe and effective way for the diagnosis and surveillance of patients with inflammatory bowel disease (IBD). It allows a noninvasive and reproducible follow-up for patients with IBD. AIM: To compare the outcomes of colonoscopy and IUS in diagnosing and monitoring patients with IBD. METHODS: …
Inflammatory Microenvironment-Responsive Microsphere Vehicles Modulating Gut Microbiota and Intestinal Inflammation for Intestinal Stem Cell Niche Remodeling in Inflammatory Bowel Disease
Publication Year: 2025 Source: ACS Nano PMID: 40125581 DOI: 10.1021/acsnano.4c17999
Intestinal stem cells (ISCs) engage in proliferation to maintain a stable stem cell population and differentiate into functional epithelial subpopulations. This intricate process is upheld by various signals derived from the host and gut microbiota, establishing an ISC niche. However, during inflammatory bowel disease (IBD), this signaling niche undergoes dramatic …
A Heavy Feeling in the Stomach: Neural Correlates of Anxiety in Crohn's Disease
Publication Year: 2025 Source: Neurogastroenterol Motil PMID: 40125714
INTRODUCTION: Crohn's disease (CD) is a chronic inflammatory condition associated with psychological stress and anxiety. Functional magnetic resonance imaging (fMRI) studies have shown differences in brain function between patients with CD and healthy controls (HC). This study aimed to compare the neural correlates of anxiety inindividuals with CD relative to …
Complications of Ileus and Bowel Obstruction During Pregnancy in Women Who Have Had Surgery for Inflammatory Bowel Disease: A Population-Based Study
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40125854 DOI: 10.14309/ajg.0000000000003425
INTRODUCTION: Women with inflammatory bowel disease (IBD) who have IBD surgery before pregnancy have an increased risk of adverse maternal and fetal outcomes. Very few studies have examined the risks of gastrointestinal complications during pregnancy in this group of women. METHODS: Using the Danish national registries, we identified live born …
Temporal trends in characteristics and management of inflammatory bowel disease
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40126153 DOI: 10.1080/00365521.2025.2478166
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) requires complex clinical management. Despite substantial advancements in endoscopy and in pharmacotherapies for patients with IBD, it remains unclear how these developments have influenced IBD incidence and clinical care. We aim to describe changes in diagnostic and therapeutic practices in IBD management. METHODS: …
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