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Colocolic intussusception with intestinal obstruction in adults secondary to a colonic lipoma
Publication Year: 2025 Source: BMJ Case Rep PMID: 40055017
We report the case of a woman in her early 60s, who presented with colocolic intussusception, leading to acute large bowel obstruction. The patient presented with colicky abdominal pain, diarrhoea mixed with blood and mucous and raised inflammatory markers. Abdominal examination revealed mild tenderness in the left lower abdomen. The …
Development of a capsule endoscopy scoring system for the early diagnosis of small bowel Crohn's disease
Publication Year: 2025 Source: J Gastroenterol PMID: 40055289
BACKGROUND: Small bowel capsule endoscopy (SBCE) is a reliable method of evaluating small bowel mucosal lesions, and its use in Crohn's disease (CD) is increasing. We previously reported useful SBCE findings for early diagnosis of CD. In the present study, we developed a scoring model for early diagnosis of CD …
STAT1 mediates the pro-inflammatory role of GBP5 in colitis
Publication Year: 2025 Source: Commun Biol PMID: 40055493 DOI: 10.1038/s42003-025-07843-0
Previous studies establish guanylate binding protein 5 (GBP5) as a driver in the development of inflammatory bowel diseases (IBDs). Here, we aim to elucidate the mechanism underlying the pro-inflammatory role of GBP5. We observe that loss of Gbp5 causes reduced colonic inflammation and decreased numbers of innate lymphoid cells (ILCs) …
c-Kit(+) cells that intercalate with crypt Lgr5(+) cells are distinctively multipotent in colonic epithelium renewal and repair
Publication Year: 2025 Source: Cell Death Differ PMID: 40055578
The colonic crypts are principally composed by Lgr5(+) stem cells and deep crypt secretory (DCS) cells. c-Kit-expressing cells mark DCS cells and supply Wnt3, EGF, and Notch signals to support their neighboring crypt bottom-intermingled Lgr5(+) cells. However, the role of c-Kit(+) cells beyond supporting Lgr5(+) cells in colonic epithelium remains …
Probiotic nanocomposite materials with excellent resistance, inflammatory targeting, and multiple efficacies for enhanced treatment of colitis in mice
Publication Year: 2025 Source: J Nanobiotechnology PMID: 40055678 DOI: 10.1186/s12951-025-03240-1
The occurrence of inflammatory bowel disease (IBD) is relevant to impaired intestinal mucosal barrier and disordered gut microbiota, subsequently leading to excessive production of reactive oxygen species (ROS) and elevated levels of inflammatory factors. Traditional therapies focus on inhibiting inflammation, but the vast majority involve non-targeted systemic administration, whose long-term …
Optimizing Hepatitis B Vaccination Strategies for Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40055899
No Abstract
Stomal calprotectin as a biomarker for assessing Crohn disease activity in patients with stomas
Publication Year: 2025 Source: Intern Med J PMID: 40055952
BACKGROUND: Faecal calprotectin is a reliable biomarker for lower gastrointestinal inflammation. However, there are limited data on the utility of calprotectin from stoma effluent. AIM: The aim of this study was to determine the performance of stomal calprotectin in identifying Crohn disease activity in those with a stoma. METHODS: Patients …
Evaluating the anti-inflammatory and antioxidant efficacy of complementary and alternative medicines (CAM) used for management of inflammatory bowel disease: a comprehensive review
Publication Year: 2025 Source: Redox Rep PMID: 40056427 DOI: 10.1080/13510002.2025.2471737
No Abstract
Evolution of Extraintestinal Manifestations in Patients With Ulcerative Colitis Post-Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis: A Single-Center Retrospective Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40056429
BACKGROUND AND AIMS: Extraintestinal manifestations (EIMs) are common in patients with ulcerative colitis (UC). However, the prevalence and associated factors of EIMs in UC patients post-restorative proctocolectomy with ileal pouch-anal anastomosis (RPC + IPAA) are not well established. METHODS: We extracted clinical, demographic, and laboratory data of all UC patients …
Superb Microvascular Imaging Is Superior to Doppler Imaging in Ruling Out Ulcerative Colitis Disease Activity
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40056435 DOI: 10.1093/ibd/izaf033
BACKGROUND: There is an unmet medical need for noninvasive techniques to determine disease activity in inflammatory bowel disease (IBD) and intestinal ultrasound (IUS) has shown promising performance in this regard. In addition to parameters such as bowel wall thickness, stratification, and mesenteric fat, color Doppler signals are used to determine …
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