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Sensor-integrated gut-on-a-chip for monitoring senescence-mediated changes in the intestinal barrier
Publication Year: 2025 Source: Lab Chip PMID: 40007323
The incidence of inflammatory bowel disease among the elderly has significantly risen in recent years, posing a growing socioeconomic burden to aging societies. Moreover, non-gastrointestinal diseases, also prevalent in this demographic, have been linked to intestinal barrier dysfunction, thus highlighting the importance of investigating aged-mediated changes within the human gut. …
Sakuranetin ameliorates experimental colitis in a gut microbiota-dependent manner
Publication Year: 2025 Source: Phytomedicine PMID: 40007342 DOI: 10.1016/j.phymed.2025.156540
BACKGROUND: The progression of inflammatory bowel disease (IBD) is closely connected with intestinal flora dysbiosis. Sakuranetin (SAK) is a natural compound with anti-inflammatory and antibiosis activities. We investigated the properties and mechanisms of SAK on IBD-like colitis. METHODS: Mice with dextran sulfate sodium (DSS)-induced colitis were accomplished to assess the …
Gut microbiota dysfunction in Crohn's disease
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40007605
INTRODUCTION: Crohn's disease (CD) results from alterations in the gut microbiota and the immune system. However, the exact metabolic dysfunctions of the gut microbiota during CD are still unclear. Here, we investigated metagenomic functions using PICRUSt2 during the course of CD to better understand microbiota-related disease mechanisms and provide new …
Surveillance colonoscopy in PSC-IBD: Some answers but more questions remain
Publication Year: 2025 Source: Endosc Int Open PMID: 40007648 DOI: 10.1055/a-2514-9742
No Abstract
Chromoendoscopy in colorectal surveillance for primary sclerosing cholangitis and inflammatory bowel disease
Publication Year: 2025 Source: Endosc Int Open PMID: 40007649
No Abstract
Patients With Experience of Hospitalization for Acute Severe Ulcerative Colitis Prefer Inpatient to Home-Based Care
Publication Year: 2025 Source: J Patient Exp PMID: 40007856
Acute severe ulcerative colitis (ASUC) comprises a severe manifestation of inflammatory bowel disease that requires close monitoring and aggressive treatment. This study aimed to evaluate the experience of patients admitted to a single tertiary service with ASUC, focusing on perception of the received therapy and preferences regarding location of care. …
Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system
Publication Year: 2025 Source: Front Pharmacol PMID: 40008128 DOI: 10.3389/fphar.2025.1436183
BACKGROUND: Upadacitinib, a Janus kinase inhibitor, has been increasingly used over the past few years to treat moderate to severe ulcerative colitis and Crohn's disease in patients who are insufficiently responsive or intolerant to tumor necrosis factor (TNF) antibodies, demonstrating notable clinical efficacy. The long-term safety of upadacitinib in extensive …
Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level
Publication Year: 2025 Source: Front Dent Med PMID: 40008255
Apical periodontitis (AP) is the local inflammation of periapical tissues originating from the dental pulp disease. Cumulative evidence suggests a link between oral and gastro-intestinal systems in both health and disease. In this context, the relationship between AP and inflammatory bowel diseases (IBDs) has not yet been elucidated. The aims …
Human small intestine: The mysterious security guard
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 40008820
No Abstract
Temporal trends in obesity and its prognostic impact in Korean patients with inflammatory bowel disease
Publication Year: 2025 Source: J Gastroenterol PMID: 40009164 DOI: 10.1007/s00535-025-02230-2
BACKGROUND: To assess the changes in body mass index (BMI) among Korean patients with inflammatory bowel disease (IBD) over a 14-year period and to explore how BMI at diagnosis impacts prognosis. METHODS: We retrospectively collected BMI and laboratory data from patients with IBD who visited the Asan Medical Center between …
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