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Axial spondyloarthritis
Publication Year: 2025 Source: Lancet PMID: 39798984
Axial spondyloarthritis manifests as a chronic inflammatory disease primarily affecting the sacroiliac joints and spine. Although chronic back pain and spinal stiffness are typical initial symptoms, peripheral (ie, enthesitis, arthritis, and dactylitis) and extra-musculoskeletal (ie, uveitis, inflammatory bowel disease, and psoriasis) manifestations are also common. Timely and accurate diagnosis is …
Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis
Publication Year: 2025 Source: BMC Gastroenterol PMID: 39799299 DOI: 10.1186/s12876-024-03571-7
BACKGROUND: Previous studies have suggested an association between inflammatory bowel disease (IBD), and pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). We aimed to examine the potential causal relationship between IBD and pancreatitis using the Mendelian randomization (MR) method. METHODS: We obtained data from genome-wide association studies (GWASs) in …
Possible linking and treatment between Parkinson's disease and inflammatory bowel disease: a study of Mendelian randomization based on gut-brain axis
Publication Year: 2025 Source: J Transl Med PMID: 39799347 DOI: 10.1186/s12967-024-06045-2
BACKGROUND: Mounting evidence suggests that Parkinson's disease (PD) and inflammatory bowel disease (IBD) are closely associated and becoming global health burdens. However, the causal relationships and common pathogeneses between them are uncertain. Furthermore, they are uncurable. Thus, we aimed to identify the causal relationships and novel therapeutic targets shared between …
[Anemia classification, prevalence and predictive factors in inflammatory bowel disease]
Publication Year: 2025 Source: Orv Hetil PMID: 39799539
Introduction: Anemia is a common complication of inflammatory bowel disease and serves as an indicator of severe disease. Objective: This study aims to evaluate the prevalence, etiology, predictive factors, and treatment of anemia in patients with inflammatory bowel disease from two tertiary centers. Method: In this retrospective, cross-sectional study, we …
[Abscisic acid - food chain and human health]
Publication Year: 2025 Source: Orv Hetil PMID: 39799540
Abscisic acid is an ancient, universal compound on different levels of phylogenetic development and helps organisms adapt to their environment. In the 1940s, attention was first given to a substance that inhibits the growth of plants, which in the mid-1960s turned out to be a phytohormone that regulates the dormant …
Quantitative assessment of transmural remission in Crohn's disease using low dose computed tomography (CT) enterography perfusion imaging: a single-centre study based on intestinal microcirculation
Publication Year: 2025 Source: Clin Radiol PMID: 39799835
No Abstract
Molecular dynamics simulations to decipher the hotspots at the allosteric site of human 5-lipoxygenase
Publication Year: 2025 Source: J Mol Graph Model PMID: 39799875
Human 5-lipoxygenase (LOX) is a non-heme, Fe-containing LOX which catalyses the conversion of arachidonic acid (AA) to leukotriene A(4) (LTA(4)). LTA(4) is subsequently converted to cysteinyl-LTs and LTB(4) that cause bronchoconstriction and act as chemotactic and chemokinetic agent on human leukocytes, respectively. Leukotrienes play significant roles in inflammation in asthma, …
Deep Learning for Classification of Inflammatory Bowel Disease Activity in Whole Slide Images of Colonic Histopathology
Publication Year: 2025 Source: Am J Pathol PMID: 39800054 DOI: 10.1016/j.ajpath.2024.12.010
Grading activity of inflammatory bowel disease (IBD) using standardized histopathological scoring systems remains challenging due to limited availability of pathologists with IBD expertise and interobserver variability. In this study, a deep learning model was developed to classify activity grades in hematoxylin and eosin-stained whole slide images (WSIs) from patients with …
Genetic correlation, pleiotropic loci and shared risk genes between major depressive disorder and gastrointestinal tract disorders
Publication Year: 2025 Source: J Affect Disord PMID: 39800072 DOI: 10.1016/j.jad.2025.01.048
BACKGROUND: Major depressive disorder (MDD) is associated with gastrointestinal tract (GIT) disorders, while genetic correlation, pleiotropic loci and shared risk genes remain to be explored. METHODS: Leveraging genome-wide association study statistics for MDD (n = 170,756), peptic ulcer disease (PUD; n = 16,666), gastroesophageal reflux disease (GORD; n = 54,854), …
AGA Clinical Practice Update on Noncolorectal Cancer Screening and Vaccinations in Patients With Inflammatory Bowel Disease: Expert Review
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39800200 DOI: 10.1016/j.cgh.2024.12.011
DESCRIPTION: The aim of this American Gastroenterological Association (AGA) Clinical Practice Update (CPU) is to provide Best Practice Advice statements for gastroenterologists and other healthcare providers who provide care to patients with inflammatory bowel disease (IBD). The focus is on IBD-specific screenings (excluding colorectal cancer screening, which is discussed separately) …
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