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Barriers and Practices in Food Reintroduction Following Exclusive Enteral Nutrition in Chinese Teenagers With Crohn's Disease: A Multi-Perspective Qualitative Study
Publication Year: 2025 Source: J Hum Nutr Diet PMID: 40588831 DOI: 10.1111/jhn.70081
BACKGROUND: Food reintroduction is a critical step for teenagers with Crohn's disease (CD) transitioning from exclusive enteral nutrition (EEN) to a normal diet. However, no standardized protocol currently guides this process. This study aimed to explore the barriers and practices of food reintroduction from the perspectives of teenagers, their caregivers …
Can current post-traumatic growth models capture the lived experience of life with a fluctuating chronic illness? Towards a new model
Publication Year: 2025 Source: Br J Health Psychol PMID: 40589134
INTRODUCTION: More than 15 million people in the UK live with a chronic illness, and this figure is only due to increase (Care and support for long term conditions, 2024). Living with these illnesses can involve surviving ongoing trauma. Such trauma can lead to psychologically distressing emotions akin to post-traumatic …
The Association of Polymorphisms in Interleukin-6 (IL-6), Interleukin-10 (IL-10), IL-6 Receptor, and IL-10 Receptor Genes with the Risk of Pediatric Inflammatory Bowel Disease
Publication Year: 2025 Source: J Inflamm Res PMID: 40589608 DOI: 10.2147/JIR.S524632
PURPOSE: Inflammatory bowel disease (IBD) results from a complex interplay between genetic, immune, and environmental factors. Despite a significant advancement in genetic studies, until now, little is known about genotype-phenotype correlations in children with IBD. Thus, we aimed to evaluate if polymorphisms in the Interleukin-6 (IL-6), Interleukin-10 (IL-10), IL-6 receptor, …
Deciphering the circadian rhythm in colorectal cancer: a bibliometric analysis of research landscape and trends
Publication Year: 2025 Source: Front Oncol PMID: 40589644
INTRODUCTION: Colorectal cancer (CRC) is a leading cause of global cancer mortality, increasingly linked to circadian rhythm disruption-a critical yet underexplored driver of tumorigenesis. METHODS: This bibliometric analysis evaluates 374 publications from the Web of Science Core Collection (1999-2024) using VOSviewer, CiteSpace, and Bibliometrix to map global research trends. RESULTS: …
A Randomized Double-Blind, Placebo-Controlled Trial of Artesunate and Curcumin in Patients With Crohn's Disease: A Pilot Study
Publication Year: 2025 Source: JGH Open PMID: 40589768
AIM: Less than half of all patients with Crohn's disease remain in remission with long-term use of azathioprine. Our aim was to assess the efficacy of Artesunate and Curcumin in maintaining remission in patients with Crohn's disease, who had ongoing evidence of disease activity despite taking azathioprine. METHODS: Patients with …
Anti-Inflammatory Peptides as Promising Therapeutics Agent Against Inflammatory Bowel Diseases: A Systematic Review
Publication Year: 2025 Source: JGH Open PMID: 40589771 DOI: 10.1002/jgh3.70212
BACKGROUND: Inflammatory bowel disease (IBD) is linked to dysregulated mucosal immunity, microbiota imbalances, and environmental factors, though its exact cause remains unknown. Current treatments often have limitations, necessitating innovative therapies. This review evaluates anti-inflammatory peptides (AIPs) as emerging therapeutic agents, focusing on their efficacy in Ulcerative Colitis and Crohn's disease. …
Pharmacoepigenetic Biomarkers in Inflammatory Bowel Diseases: A Narrative Review
Publication Year: 2025 Source: Yale J Biol Med PMID: 40589936 DOI: 10.59249/FTXB7704
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, autoimmune disorder characterized by inflammation along the gastrointestinal tract. Global prevalence of the disease is increasing and patients often experience delays in diagnosis accessing effective therapy, highlighting an urgent need to develop a predictive biomarker …
Children With Inflammatory Bowel Diseases are Disadvantaged by Current Drug Approval Policies: A Call for Urgent Change
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40589946 DOI: 10.1093/crocol/otaf036
Treatment of pediatric inflammatory bowel disease (IBD) is significantly hindered by the lack of US Food and Drug Administration-approved biologic and small-molecule medications. This review explains the burdens faced by children with IBD because of this problem and appraises the marked historical timeline differences in medication approval between adults and …
Editorial: Current trends and future management of IBD, volume II
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40589970 DOI: 10.3389/fmed.2025.1637213
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EXPRESS: Impact of Anxiety and Depression on Hospitalization Outcomes and Healthcare Costs in Ulcerative Colitis & Crohn's Disease: A National Inpatient Sample Analysis
Publication Year: 2025 Source: J Investig Med PMID: 40590472 DOI: 10.1177/10815589251346962
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is associated with high rates of anxiety and depression, which can significantly influence disease outcomes through the gut-brain axis. This study utilized the National Inpatient Sample (NIS) database (2018-2021) to assess the impact of these psychiatric comorbidities on …
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