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Safety, Pharmacokinetics, and Clinical Efficacy of ADS051, a Neutrophil Modulator, in Ulcerative Colitis: Results of a Randomized Phase 1b Trial

Publication Year: 2024 Source: Am J Gastroenterol PMID: 39787364

No Abstract

Infliximab and Adalimumab in the Treatment of Fistulizing Crohn's Disease: A Propensity Score-Matched Analysis From the Prospective Persistence Australian National IBD Cohort (PANIC4) Study

Publication Year: 2024 Source: Am J Gastroenterol PMID: 39787365 DOI: 10.14309/ajg.0000000000003271

INTRODUCTION: There are spare data on comparative medication efficacy in fistulizing Crohn's disease (FCD), particularly with immunomodulator cotherapy. Persistence is a unique way to assess real-world outcomes. METHODS: The persistence of all dispensed biological agents was analyzed from the Australian Pharmaceutical Benefits Scheme registry data 2005-2021 for FCD. Propensity score …

A Practical Guide to Diet and IBD

Publication Year: 2024 Source: Am J Gastroenterol PMID: 39787366 DOI: 10.14309/ajg.0000000000003266

No Abstract

Does the Failure to Provide Equitable Access to Treatment Lead to Action by NHS Organisations? The Case of Biologics for South Asians with Inflammatory Bowel Disease

Publication Year: 2024 Source: J Law Med PMID: 39789688

No Abstract

Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance

Publication Year: 2024 Source: Gastro Hep Adv PMID: 39790237 DOI: 10.1016/j.gastha.2024.08.012

BACKGROUND AND AIMS: Chronic fatigue is common in patients with inflammatory bowel disease (IBD). The gut microbiota, specifically, microbial diversity and butyrate-producing bacteria have been linked to the fatigue pathogenesis. High-dose oral thiamine reduces fatigue, potentially through gut microbiota modification. In this study, we investigated how the gut microbiota influences …

Malakoplakia Associated with Diarrhoea and Colonic Lesions After Rituximab Treatment

Publication Year: 2024 Source: Eur J Case Rep Intern Med PMID: 39790856 DOI: 10.12890/2024_005067

Malakoplakia is a rare granulomatous condition that occurs due to defective lysosomal digestion during phagocytosis and can mimic inflammatory bowel disease (IBD) or malignancies, particularly in immunosuppressed patients. We report the case of a 62-year-old male with IgG4-related orbitopathy, who developed persistent diarrhoea and colonic lesions 6 weeks after receiving …

Development and Examination of an Educational Program Combining E-Learning and Face-to-Face Training That Nurtures Inflammatory Bowel Disease Nurse Specialists

Publication Year: 2024 Source: Inflamm Intest Dis PMID: 39791117 DOI: 10.1159/000541485

INTRODUCTION: The number of patients with inflammatory bowel disease (IBD) in Japan has continued to increase, leading to diverse and complex patient backgrounds. Despite these challenges, the education of IBD nurse specialists has not kept pace with the evolving circumstances. Therefore, our research aimed to develop and validate an educational …

GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth

Publication Year: 2024 Source: J Immunother Cancer PMID: 39794935

No Abstract

Changes in the Phenotype and Metabolism of Peritoneal Macrophages in Mucin-2 Knockout Mice and Partial Restoration of Their Functions In Vitro After L-Fucose Treatment

Publication Year: 2024 Source: Int J Mol Sci PMID: 39795876 DOI: 10.3390/ijms26010013

In the development of inflammatory bowel disease (IBD), peritoneal macrophages contribute to the resident intestinal macrophage pool. Previous studies have demonstrated that oral administration of L-fucose exerts an immunomodulatory effect and repolarizes the peritoneal macrophages in vivo in mice. In this study, we analyzed the phenotype and metabolic profile of …

Key Interleukins in Inflammatory Bowel Disease-A Review of Recent Studies

Publication Year: 2024 Source: Int J Mol Sci PMID: 39795980 DOI: 10.3390/ijms26010121

Inflammatory bowel disease (IBD) is an immune disorder of the gastrointestinal tract with a complex aetiopathogenesis, whose development is influenced by many factors. The prevalence of IBD is increasing worldwide, in both industrialized and developing countries, making IBD a global health problem that seriously affects quality of life. In 2019, …

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