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Regulation of Colonic Inflammation and Macrophage Homeostasis of IFN-γ-Primed Canine AMSCs in Experimental Colitis in Mice
Publication Year: 2024 Source: Animals (Basel) PMID: 39595338 DOI: 10.3390/ani14223283
Mesenchymal stem cells (MSCs) have shown potential in treating immune-mediated diseases due to their immunomodulatory properties, which can be enhanced by priming with inflammatory cytokines like interferon-gamma (IFN-gamma). This study evaluates the therapeutic effects of IFN-gamma-primed canine adipose tissue-derived MSCs (AMSCs) in a mouse model of inflammatory bowel disease (IBD). …
Gut Bacterial Composition and Nutritional Implications in Mexican and Spanish Individuals with Inflammatory Bowel Disease Compared to Healthy Controls
Publication Year: 2024 Source: Int J Mol Sci PMID: 39595956 DOI: 10.3390/ijms252211887
The intestinal microbiota plays a key role in the pathogenesis of inflammatory bowel disease (IBD), with its composition varying based on geographic location and dietary factors. This study was performed to examine and compare the bacterial composition of the gut microbiota in Mexican and Spanish individuals with IBD and healthy …
A Small Intestinal Helminth Infection Alters Colonic Mucus and Shapes the Colonic Mucus Microbiome
Publication Year: 2024 Source: Int J Mol Sci PMID: 39596084
No Abstract
A New Probiotic Formulation Promotes Resolution of Inflammation in a Crohn's Disease Mouse Model by Inducing Apoptosis in Mucosal Innate Immune Cells
Publication Year: 2024 Source: Int J Mol Sci PMID: 39596135
No Abstract
Underneath the Gut-Brain Axis in IBD-Evidence of the Non-Obvious
Publication Year: 2024 Source: Int J Mol Sci PMID: 39596193 DOI: 10.3390/ijms252212125
The gut-brain axis (GBA) plays a pivotal role in human health and wellness by orchestrating complex bidirectional regulation and influencing numerous critical processes within the body. Over the past decade, research has increasingly focused on the GBA in the context of inflammatory bowel disease (IBD). Beyond its well-documented effects on …
Microsomal Prostaglandin E Synthase-1 Controls Colonic Prostaglandin E(2) Production and Exerts a Protective Effect on Colitis Induced by Trinitrobenzene Sulfonic Acid in Mice
Publication Year: 2024 Source: Int J Mol Sci PMID: 39596393 DOI: 10.3390/ijms252212326
Microsomal prostaglandin E synthase-1 (mPGES-1) is an isozyme of the prostaglandin (PG) E synthase that acts downstream of cyclooxygenase and catalyzes the conversion of PGH(2) to PGE(2). The impact of genetic deletion of mPGES-1 on the development of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis, a well-established model of inflammatory bowel disease …
Participation of Semaphorin Family and Plexins in the Clinical Course of Patients with Inflammatory Bowel Disease
Publication Year: 2024 Source: Int J Mol Sci PMID: 39596507 DOI: 10.3390/ijms252212442
Semaphorins are an immunoregulatory protein family. Plexins bind semaphorins (SEMAs) and can form receptor complexes that give them chemotactic capacity. The role and expression profile of semaphorins and plexins in inflammatory bowel disease (IBD) is currently unknown. AIM: Characterize the semaphorins and plexins gene and protein expression in intestinal tissue …
Metabolic Transcriptional Activation in Ulcerative Colitis Identified Through scRNA-seq Analysis
Publication Year: 2024 Source: Genes (Basel) PMID: 39596612
No Abstract
A Novel Quinoline Inhibitor of the Canonical NF-κB Transcription Factor Pathway
Publication Year: 2024 Source: Biology (Basel) PMID: 39596865
No Abstract
Transcriptional Responses of Lacticaseibacillus rhamnosus to TNFα, IL-6, IL-8, and IL-10 Cytokines
Publication Year: 2024 Source: Biology (Basel) PMID: 39596886 DOI: 10.3390/biology13110931
The interaction between gut microbiota and the host immune system is a complex and understudied field, with cytokines like TNFalpha, IL-6, IL-8, and IL-10 playing pivotal roles. Commensal bacteria, including lactobacilli, respond to these cytokines through adaptive mechanisms that support their survival and function within the gut. While the influence …
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