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Berberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling
Publication Year: 2024 Source: BMC Biol PMID: 39617924 DOI: 10.1186/s12915-024-02078-7
BACKGROUND: Inflammatory bowel disease (IBD), a persistent gastrointestinal disease, is featured with impaired gut immunity. Previous studies have demonstrated that tuft cells can regulate the intestinal type 2 immune response by activating downstream ILC2 and Th2 cells and repair gut barrier upon invasion of parasitic helminths, bacteria, protozoans, and enteritis …
Human Papillomavirus Infection and Autoimmune Diseases: A Two-Sample Bidirectional Mendelian Randomization Study
Publication Year: 2024 Source: Int J Rheum Dis PMID: 39618109 DOI: 10.1111/1756-185X.15430
BACKGROUND: Although earlier observational studies have revealed a connection between human papillomavirus (HPV) infection and several autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), the exact causative mechanism underlying this association is still unknown. METHODS: This two-sample bidirectional MR study was conducted based on publicly released …
Immune Thrombocytopenic Purpura (ITP) With Ulcerative Colitis (UC)
Publication Year: 2024 Source: Cureus PMID: 39618596 DOI: 10.7759/cureus.72778
Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn's disease. A relapsing, immune-modulated illness, it causes inflammation of the small and large intestines. UC is sometimes associated with extra-intestinal manifestations, including autoimmune cytopenias. Immune thrombocytopenic purpura (ITP) is a rare disorder which may induce an antibody-mediated, isolated reduction in …
Small Bowel Obstruction Secondary to Meckel's Diverticulum: A Rare Complication
Publication Year: 2024 Source: Cureus PMID: 39618772
No Abstract
Modulation of Orosomucoid-like Protein 3 Activity in the Management of Inflammatory Bowel Disease
Publication Year: 2024 Source: J Biotechnol Biomed PMID: 39619146 DOI: 10.26502/jbb.2642-91280167
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a chronic and relapsing condition characterized by persistent inflammation of the gastrointestinal tract. The complex pathogenesis of IBD involves a combination of genetic, environmental, and immune factors, which complicates the achievement of long-term remission. Lower abdominal pain, stomach cramps, …
Association of TMAO levels with indicators of ulcerative colitis activity
Publication Year: 2024 Source: Caspian J Intern Med PMID: 39619747 DOI: 10.22088/cjim.16.1.114
BACKGROUND: The diagnosis of ulcerative colitis (UC) today is limited to a small number of biomarkers. Trimethylamine-N-oxide (TMAO) is the product of reactions resulting from the degradation of dietary-free choline, phosphatidylcholine, and carnitine metabolism by the intestinal microbiota. Earlier studies showed his involvement in the pathogenesis of UC. To study …
Exposure to Environmental Pollutants and Risk of Diarrhea: A Systematic Review
Publication Year: 2024 Source: Environ Health Insights PMID: 39619770
No Abstract
Reverse switching from the biosimilar SB2 to the originator infliximab in previously switched patients with inflammatory bowel diseases: results of a prospective long-term cohort study
Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 39619829 DOI: 10.1177/17562848241301887
BACKGROUND: Data regarding multiple switches including reverse switching between infliximab and its biosimilars are scarce in the field of inflammatory bowel diseases (IBD). OBJECTIVES: We investigated the clinical effectiveness as primary outcome measure after repeated switches. Secondary endpoints included C-reactive protein (CRP) levels, immunogenicity (trough levels (TL); anti-drug antibodies (ADA), …
Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries
Publication Year: 2024 Source: Ther Adv Musculoskelet Dis PMID: 39620047 DOI: 10.1177/1759720X241303316
BACKGROUND: Inflammatory bowel disease (IBD) affects 5%-10% of ankylosing spondylitis (AS) patients. Prior data suggest AS patients with IBD may have more severe disease and lower HLA-B27 prevalence. Yet, little is known about potential distinctions in AS with IBD compared to those without IBD. OBJECTIVE: To investigate the clinical characteristics …
Defective Atg16l1 in intestinal epithelial cells links to altered fecal microbiota and metabolic shifts during pregnancy in mice
Publication Year: 2024 Source: Gut Microbes PMID: 39620359 DOI: 10.1080/19490976.2024.2429267
Throughout gestation, the female body undergoes a series of transformations, including profound alterations in intestinal microbial communities. Changes gradually increase toward the end of pregnancy and comprise reduced alpha-diversity of microbial communities and an increased propensity for energy harvest. Despite the importance of the intestinal microbiota for the pathophysiology of …
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