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APEX1 in intestinal epithelium triggers neutrophil infiltration and intestinal barrier damage in ulcerative colitis
Publication Year: 2024 Source: Free Radic Biol Med PMID: 39389211 DOI: 10.1016/j.freeradbiomed.2024.10.260
Ulcerative colitis (UC) can lead to the generation of large amounts of reactive oxygen species and DNA damage. DNA repair caused by base excision repair (BER) enzymes is an important mechanism for maintaining genomic integrity. However, the specific relationship between the function of BER enzymes and UC remains unclear. To …
A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues
Publication Year: 2024 Source: Nat Commun PMID: 39389974
No Abstract
Dysbiotic signatures and diagnostic potential of gut microbial markers for inflammatory bowel disease in Korean population
Publication Year: 2024 Source: Sci Rep PMID: 39390011 DOI: 10.1038/s41598-024-74002-6
No Abstract
Goat Milk Exosomes Ameliorate Ulcerative Colitis in Mice through Modulation of the Intestinal Barrier, Gut Microbiota, and Metabolites
Publication Year: 2024 Source: J Agric Food Chem PMID: 39390385
No Abstract
Mutational analysis differentiating sporadic carcinomas from colitis-associated colorectal carcinomas
Publication Year: 2024 Source: Cell Commun Signal PMID: 39390564 DOI: 10.1186/s12964-024-01856-8
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that is associated with increased risk of developing colitis-associated carcinoma (CAC). The genetic profile of CACs is fairly similar to the sporadic colorectal carcinomas (sCRCs), although showing certain differences in the timing and sequence of alterations that contribute to …
Lateral flow test versus enzyme-linked immunosorbent assay to measure infliximab trough concentrations: A head-to-head comparison
Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 39390697 DOI: 10.1002/jpn3.12372
OBJECTIVES: Infliximab is an antitumour necrosis factor agent used to treat inflammatory bowel disease (IBD). Measurement of infliximab trough concentrations (C-troughs) are used to optimize drug exposure and improve outcomes. Currently, enzyme-linked immunosorbent assays (ELISAs) are used predominantly for this purpose. Novel lateral flow immunoassays provide a rapid result. METHODS: …
Importance of high suspicion of intestinal perforation in blunt abdominal injury in patients with inflammatory bowel disease
Publication Year: 2024 Source: J Surg Case Rep PMID: 39391202
No Abstract
Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota
Publication Year: 2024 Source: Front Immunol PMID: 39391314 DOI: 10.3389/fimmu.2024.1375781
INTRODUCTION: Ulcerative colitis, a subtype of chronic inflammatory bowel disease (IBD), is characterized by relapsing colonic inflammation and ulcers. The traditional Chinese herbal formulation Huang Lian Jie Du (HLJD) decoction is used clinically to treat diarrhea and colitis. However, the mechanisms associated with the effects of treatment remain unclear. This …
A Curious Case of Medium-Vessel Vasculitis
Publication Year: 2024 Source: Cureus PMID: 39391399
No Abstract
Assessing the Role of Flexible Sigmoidoscopy for Patients With Positive Fecal Immunochemical Test (FIT) and Rectal Bleeding as a Sole Symptom Within the Fast-Track Pathway
Publication Year: 2024 Source: Cureus PMID: 39391448 DOI: 10.7759/cureus.69060
Background Rectal bleeding is a frequent symptom, with causes ranging from benign conditions to serious diseases like colorectal cancer (CRC) and inflammatory bowel disease (IBD). In the UK, the two-week wait (2WW) referral pathway, which includes the fecal immunochemical test (FIT), plays a key role in triaging suspected CRC cases. …
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