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Kui-Jie-Ling capsule inhibits ulcerative colitis by modulating inflammation and gut microbiota
Publication Year: 2024 Source: J Gastroenterol Hepatol PMID: 39406549
No Abstract
Immunomodulatory effect of Dicrocoelium dendriticum ova on DSS-induced experimental colitis in C57BL/6 mouse
Publication Year: 2024 Source: Sci Rep PMID: 39406758 DOI: 10.1038/s41598-024-73692-2
Inflammatory bowel disease (IBD) significantly diminishes an individual's quality of life and increases the risk of colorectal cancer. Recent clinical and experimental findings suggest that infection with parasitic helminths may suppress the development of certain inflammatory conditions. The objective of this study was to evaluate the immunoregulatory effects of Dicrocoelium …
Identification of novel proteins in inflammatory bowel disease based on the gut-brain axis: a multi-omics integrated analysis
Publication Year: 2024 Source: Clin Proteomics PMID: 39407121 DOI: 10.1186/s12014-024-09511-7
BACKGROUND: The gut-brain axis has garnered increasing attention, with observational studies suggesting its involvement in the disease activity and progression of inflammatory bowel disease (IBD), but the precise mechanisms remain unclear. MATERIALS AND METHODS: In this study, we aimed to investigate "novel proteins" underlying IBD in the brain using a …
Review of MrsFreqPhase methods: methods designed to estimate statistically malaria parasite multiplicity of infection, relatedness, frequency and phase
Publication Year: 2024 Source: Malar J PMID: 39407242 DOI: 10.1186/s12936-024-05119-2
Malaria parasites are haploid within humans, but infections often contain genetically distinct groups of clonal parasites. When the per-infection number of genetically distinct clones (i.e., the multiplicity of infection, MOI) exceeds one, and per-infection genetic data are generated in bulk, important information are obfuscated. For example, the MOI, the phases …
Unveiling the overlooked fungi: the vital of gut fungi in inflammatory bowel disease and colorectal cancer
Publication Year: 2024 Source: Gut Pathog PMID: 39407244 DOI: 10.1186/s13099-024-00651-7
The fungi of the human microbiota play important roles in the nutritional metabolism and immunological balance of the host. Recently, research has increasingly emphasised the role of fungi in modulating inflammation in intestinal diseases and maintaining health in this environment. It is therefore necessary to understand more clearly the interactions …
Biochemical Modulators of Tight Junctions (TJs): Occludin, Claudin-2 and Zonulin as Biomarkers of Intestinal Barrier Leakage in the Diagnosis and Assessment of Inflammatory Bowel Disease Progression
Publication Year: 2024 Source: Molecules PMID: 39407507 DOI: 10.3390/molecules29194577
BACKGROUND: Considering the increasing worldwide prevalence of inflammatory bowel disease (IBD), the early diagnosis of this disease is extremely important. However, non-invasive diagnostic methods remain limited, while invasive techniques are the most commonly used in daily practice. Therefore, there is a serious need to find new non-invasive biomarkers of IBD. …
Microscopic Colitis: An Underestimated Disease of Growing Importance
Publication Year: 2024 Source: J Clin Med PMID: 39407743
No Abstract
Clinical Expression of Familial Hypercholesterolemia in Patients from France and French Canada Carrying Identical-by-Descent Pathogenic LDLR Gene Variants: A Proof-of-Concept Study
Publication Year: 2024 Source: J Clin Med PMID: 39407785 DOI: 10.3390/jcm13195725
Background: Studying patients carrying identical-by-descent (IBD) pathogenic gene variants allows us to control for the disease-causing genetic background and to more accurately document the impact of modifiers. Familial hypercholesterolemia (FH) is characterized by elevated low-density lipoprotein cholesterol (LDL-c) levels and premature atherosclerosis and is often caused by defects in the …
Alterations of the Gut Microbiome and TMAO Levels in Patients with Ulcerative Colitis
Publication Year: 2024 Source: J Clin Med PMID: 39407853 DOI: 10.3390/jcm13195794
Background: Ulcerative colitis (UC) is an idiopathic and heterogeneous large intestine disease, characterized by chronic mucosa and submucosa inflammation. Alteration of the intestinal microbiome in UC may be responsible for modifications in metabolite production. Aim: To investigate the microbiota status and trimethylamine-N-oxide (TMAO) metabolite levels in patients with UC according …
Dietary Determinants of Metabolic and Gut Microbial Health in Patients with Inflammatory Bowel Disease
Publication Year: 2024 Source: Nutrients PMID: 39408201 DOI: 10.3390/nu16193233
Background: Diet has been linked to gut dysbiosis and the onset, course, and response to treatment of patients with IBD and metabolic disease. Methods: This single-centre prospective case-control study investigated the relationship between dietary intake, metabolic profile, and stool microbial composition in 57 individuals with IBD in clinical remission and …
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