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Harnessing the Anti-Inflammatory Properties of Polyphenols in the Treatment of Inflammatory Bowel Disease
Publication Year: 2024 Source: Int J Biol Sci PMID: 39494333 DOI: 10.7150/ijbs.98107
Inflammatory bowel disease (IBD) encompasses a spectrum of chronic inflammatory conditions affecting the gastrointestinal tract, notably ulcerative colitis (UC) and Crohn's disease (CD). Both UC and CD result from the interplay between genetic and environmental factors that trigger an exacerbated immune response against gut microorganisms, leading to non-resolving inflammatory damage …
The Incidence and Predictive Factors of Thromboembolism During Hospitalizations for Inflammatory Bowel Disease Flare-Ups: A Retrospective Cohort Study in Taiwan
Publication Year: 2024 Source: J Eval Clin Pract PMID: 39494705 DOI: 10.1111/jep.14231
BACKGROUND/AIMS: Thromboembolism (TE) notably increase morbidity and mortality among inflammatory bowel disease (IBD) patients. Despite ECCO's 2024 guidelines advocating routine anticoagulant prophylaxis, its application in Asia remains inconsistent due to a lack of regional studies. This research investigates the incidence and predictors of TE during IBD-related hospitalizations in Taiwan, aiming …
The Effectiveness of Oral Vancomycin on Inflammatory Bowel Disease in Patients With Primary Sclerosing Cholangitis: A Systematic Review
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 39495039 DOI: 10.1093/ibd/izae257
BACKGROUND: Approximately 70% of primary sclerosing cholangitis (PSC) patients have inflammatory bowel disease (IBD). The IBD therapies currently used to treat PSC-IBD patients have side effects and can be costly. Oral vancomycin (OV)-a safe, economical, and convenient therapy-has been reported to be a salvage therapy in refractory PSC-IBD patients. This …
Extended Monitoring for Transition to Oral Corticosteroids in Acute Severe Ulcerative Colitis May Be Unnecessarily Prolonging Length of Stay
Publication Year: 2024 Source: Dig Dis Sci PMID: 39495414 DOI: 10.1007/s10620-024-08679-0
BACKGROUND: There is no guideline regarding whether patients treated with intravenous corticosteroids for acute severe ulcerative colitis (ASUC) should be monitored in the hospital after transitioning to oral steroids. Our study aimed to: (1) compare rates of oral steroid transition failure and 30-day readmission between ASUC hospitalizations with extended inpatient …
Inflammatory Bowel Disease Knowledge and Education Among Healthcare Professional Groups
Publication Year: 2024 Source: Dig Dis Sci PMID: 39495417
No Abstract
The gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis
Publication Year: 2024 Source: PLoS Negl Trop Dis PMID: 39495798 DOI: 10.1371/journal.pntd.0012645
BACKGROUND: Inflammatory bowel disease (IBD) increases the risk of colorectal cancer, and it has the potential to diminish the quality of life. Clinical and experimental evidence demonstrate protective aspects of parasitic helminth infection against IBD. However, studies on the inhibition of inflammation by helminth infection have overlooked a key determinant …
Overcoming problematic growth phenotypes in organoids from patients with monogenic GI disease
Publication Year: 2024 Source: PLoS One PMID: 39495812 DOI: 10.1371/journal.pone.0309072
Patient-derived organoids provide a unique model system to explore disease-causing mutations ex vivo. By using organoids from duodenal or colonic biopsies of pediatric patients with intestinal epithelial disorders, we can directly assay the patient cells to tailor treatment to their unique disease state. The advent of organoid technology from patients …
Research progress of probiotics and their protective strategy in the field of inflammatory bowel disease treatment: A review
Publication Year: 2024 Source: Medicine (Baltimore) PMID: 39495980 DOI: 10.1097/MD.0000000000040401
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease characterized by recurrent episodes and difficult-to-cure symptoms. Although the pathogenesis of IBD is closely related to host genetic susceptibility, intestinal microbiota, environmental factors, and immune responses, leading to mucosal damage and increased intestinal permeability. Intestinal mucosal injury in IBD patients …
Improved injection site reactions after switching from adalimumab reference to adalimumab biosimilar LBAL for ulcerative colitis: A case report
Publication Year: 2024 Source: Medicine (Baltimore) PMID: 39496006
No Abstract
In active ulcerative colitis, risankizumab induced and maintained remission
Publication Year: 2024 Source: Ann Intern Med PMID: 39496179
No Abstract
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