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Intestinal Epithelial Cell Brush Border Membrane Cl:HCO(3) Exchanger Regulation by Mast Cells in Chronic Ileitis
Publication Year: 2024 Source: Int J Mol Sci PMID: 39456989 DOI: 10.3390/ijms252011208
Malabsorption of NaCl is the primary cause of diarrhea in inflammatory bowel disease (IBD). Coupled NaCl absorption occurs via the dual operation of Na:H and Cl:HCO(3) exchange in the brush border membrane (BBM) of villus cells. Cl:HCO(3) exchange is mediated by BBM transporters DRA (downregulated in adenoma) and PAT1 (putative …
The Gut Microbiome Advances Precision Medicine and Diagnostics for Inflammatory Bowel Diseases
Publication Year: 2024 Source: Int J Mol Sci PMID: 39457040 DOI: 10.3390/ijms252011259
The gut microbiome emerges as an integral component of precision medicine because of its signature variability among individuals and its plasticity, which enables personalized therapeutic interventions, especially when integrated with other multiomics data. This promise is further fueled by advances in next-generation sequencing and metabolomics, which allow in-depth high-precision profiling …
The First Case of Schaumann Bodies in Pediatric Very Early Onset Crohn's Disease: Case Report and Literature Review
Publication Year: 2024 Source: Children (Basel) PMID: 39457181
No Abstract
Early Symptoms in Children with Inflammatory Bowel Disease: Implications for Subsequent Bone Mineral Deficiency
Publication Year: 2024 Source: Children (Basel) PMID: 39457188 DOI: 10.3390/children11101223
BACKGROUND: Inflammatory bowel disease (IBD) is associated with multiple factors that influence bone metabolism. This study aimed to compare the clinical manifestations and diagnostic parameters of patients with Crohn's disease (CD) and ulcerative colitis (UC) at the time of diagnosis, as well as to assess their relationship with subsequent bone …
Evaluation of Four Forensic Investigative Genetic Genealogy Analysis Approaches with Decreased Numbers of SNPs and Increased Genotyping Errors
Publication Year: 2024 Source: Genes (Basel) PMID: 39457453 DOI: 10.3390/genes15101329
Background: Forensic investigative genetic genealogy (FIGG) has developed rapidly in recent years and is considered a novel tool for crime investigation. However, crime scene samples are often of low quality and quantity and are challenging to analyze. Deciding which approach should be used for kinship inference in forensic practice remains …
Evaluation of Selenium Concentrations in Patients with Crohn's Disease and Ulcerative Colitis
Publication Year: 2024 Source: Biomedicines PMID: 39457481 DOI: 10.3390/biomedicines12102167
BACKGROUND/OBJECTIVES: In this study, serum selenium levels in patients with Crohn's disease (CD) and ulcerative colitis (UC) were evaluated to identify potential predictive markers of disease activity. Conducted in 100 inflammatory bowel disease (IBD) patients (54 CD, 46 UC) and 100 healthy controls, this research provides novel insights through focusing …
Modelling a Western Lifestyle in Mice: A Novel Approach to Eradicating Aerobic Spore-Forming Bacteria from the Colonic Microbiome and Assessing Long-Term Clinical Outcomes
Publication Year: 2024 Source: Biomedicines PMID: 39457587
No Abstract
Spasmolytic Activity and Anti-Inflammatory Effect of Novel Mebeverine Derivatives
Publication Year: 2024 Source: Biomedicines PMID: 39457637
No Abstract
Targeting the Intestinal Microbiota: A Novel Direction in the Treatment of Inflammatory Bowel Disease
Publication Year: 2024 Source: Biomedicines PMID: 39457652
No Abstract
Oral Spore-Based Probiotic Supplementation Alters Post-Prandial Expression of mRNA Associated with Gastrointestinal Health
Publication Year: 2024 Source: Biomedicines PMID: 39457699 DOI: 10.3390/biomedicines12102386
Background/Objectives: Unregulated post-prandial dietary endotoxemia may accumulate over time and underlie the development of chronic disease (e.g., leaky gut, inflammatory bowel disease, etc.), for which oral probiotic supplementation may be a prophylactic. The purpose of this study was to determine if 45 d of oral spore-based probiotic supplementation altered gastrointestinal-associated …
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