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Therapeutic Effects of Zanthoxyli Pericarpium on Intestinal Inflammation and Network Pharmacological Mechanism Analysis in a Dextran Sodium Sulfate-Induced Colitis Mouse Model
Publication Year: 2024 Source: Nutrients PMID: 39458516 DOI: 10.3390/nu16203521
(1) Background: IBD (inflammatory bowel disease) is characterized by chronic intestinal inflammation leading to persistent symptoms and a lack of effective treatments. ZP (Zanthoxyli Pericarpium) has been used in traditional Chinese medicine for its anti-inflammatory and antioxidant properties for the management of intestinal disorders. (2) Methods: This study aimed to …
Inhibition of Angiogenesis and Effect on Inflammatory Bowel Disease of Ginsenoside Rg3-Loaded Thermosensitive Hydrogel
Publication Year: 2024 Source: Pharmaceutics PMID: 39458575 DOI: 10.3390/pharmaceutics16101243
Background: Inflammatory bowel disease (IBD), characterized by chronic inflammation of the digestive tract, involves angiogenesis as a key pathogenic mechanism. Ginsenoside Rg3, derived from the traditional Chinese herb ginseng, is recognized for its anti-angiogenic properties but is limited by low oral bioavailability. This necessitates the development of an alternative delivery …
The Efficacy, Safety, and Persistence of Therapy after Non-Medical Switching from an Originator Adalimumab in Inflammatory Bowel Disease: Real-Life Experience from Two Tertiary Centres
Publication Year: 2024 Source: Pharmaceuticals (Basel) PMID: 39458960 DOI: 10.3390/ph17101319
During the last two decades, an increased number of molecules with multiple mechanisms of action have been approved for the treatment of inflammatory bowel disease (IBD), with a substantial increase in the costs related to therapy, which has become a concern for payers, regulators, and healthcare professionals. Biosimilars are biologic …
Comparison of Pudendal Nerve Block and Spinal Anesthesia in Proctological Surgeries: Efficacy, Safety, and Patient Outcomes
Publication Year: 2024 Source: Medicina (Kaunas) PMID: 39459438
No Abstract
Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Inflammatory Bowel Diseases: A Pilot Study
Publication Year: 2024 Source: Life (Basel) PMID: 39459526 DOI: 10.3390/life14101226
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by persistent inflammation and is often associated with metabolic dysfunction-associated steatotic liver disease (MASLD). IBD patients are at risk of developing MASLD due to shared risk factors such as gut dysbiosis and systemic inflammation. The new MASLD nomenclature emphasizes the link between liver …
The Influence of the Gut Microbiota on Host Health: A Focus on the Gut-Lung Axis and Therapeutic Approaches
Publication Year: 2024 Source: Life (Basel) PMID: 39459579
No Abstract
New Role of the Serotonin as a Biomarker of Gut-Brain Interaction
Publication Year: 2024 Source: Life (Basel) PMID: 39459580 DOI: 10.3390/life14101280
Serotonin (5-hydroxytryptamine: 5-HT), a neurotransmitter that regulates mood in the brain and signaling in the gut, has receptors throughout the body that serve various functions, especially in the gut and brain. Selective serotonin reuptake inhibitors (SSRIs) are used to treat depression, but their efficacy is uncertain. Depression is often associated …
Gastrointestinal Sequelae of COVID-19: Investigating Post-Infection Complications-A Systematic Review
Publication Year: 2024 Source: Viruses PMID: 39459851
No Abstract
Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulation in Patients with Inflammatory Bowel Disease
Publication Year: 2024 Source: Viruses PMID: 39459904 DOI: 10.3390/v16101570
Inflammatory bowel disease (IBD) includes patients affected by Crohn's disease or ulcerative colitis. IBD is thought to be a chronic immune-mediated disease, but its origin remains elusive, and this limits new therapeutic approaches. Human endogenous retroviruses (HERVs) originate from ancestral infections and represent 8% of the human genome. HERVs are …
Motor, mood, and memory impairments persist during remission periods in chronic colitis and are influenced by neuroinflammation and sex
Publication Year: 2024 Source: FASEB J PMID: 39460563
No Abstract
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