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Oral Administration of Bioactive Nanoparticulates for Inflammatory Bowel Disease Therapy by Mitigating Oxidative Stress and Restoring Intestinal Microbiota Homeostasis
Publication Year: 2024 Source: Mol Pharm PMID: 39462848 DOI: 10.1021/acs.molpharmaceut.4c00499
The management of inflammatory bowel disease (IBD) continues to pose significant challenges due to the absence of curative therapies and a high rate of recurrence. Therefore, it is imperative to explore novel approaches to enhance the efficacy of IBD therapy. Herein, a bioactive nanoparticulate s is tailored designed to achieve …
Exploring photobiomodulation in the management of bowel diseases: a concise critical review
Publication Year: 2024 Source: Lasers Med Sci PMID: 39463190 DOI: 10.1007/s10103-024-04217-6
The complexity of the gastrointestinal system plays a crucial role in coordinating essential processes such as digestion, nutrient absorption, and waste elimination. inflammatory bowel diseases (IBD) pose significant treatment challenges due to their complex aetiology and varied symptoms. Conventional therapeutic approaches often involve pharmacological interventions, which may have side effects …
Laparoscopic Robotic-Assisted Restorative Proctocolectomy and Ileal J-Pouch-Anorectal Anastomosis in Children: Shifting to a Two Stage-Approach
Publication Year: 2024 Source: J Laparoendosc Adv Surg Tech A PMID: 39463272 DOI: 10.1089/lap.2023.0382
Background: Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) is the gold standard surgical treatment for patients with ulcerative colitis (UC) unresponsive to medical therapy and those with familial adenomatous polyposis. Robotic IPAA is a safe and feasible option for the surgical treatment of UC in children. The feasibility of …
Safety and Efficacy of Upadacitinib in Crohn's Disease: An Updated Systematic Review
Publication Year: 2024 Source: Cureus PMID: 39463627
No Abstract
Shared Pathophysiology of Inflammatory Bowel Disease and Psoriasis: Unraveling the Connection
Publication Year: 2024 Source: Cureus PMID: 39463646 DOI: 10.7759/cureus.70148
Inflammatory bowel disease (IBD) and psoriasis are both chronic autoimmune diseases with a unique set of characteristics. Interestingly, both conditions share considerable overlap in their pathophysiological mechanisms and immune dysregulation. Epidemiological studies validate the relationship by showing a greater prevalence of co-occurrence of the two disorders. At the genetic level, …
eQTL in diseased colon tissue identifies novel target genes associated with IBD
Publication Year: 2024 Source: bioRxiv PMID: 39464142 DOI: 10.1101/2024.10.14.618229
Genome-wide association studies (GWAS) have identified over 300 loci associated with the inflammatory bowel diseases (IBD), but putative causal genes for most are unknown. We conducted the largest disease-focused expression quantitative trait loci (eQTL) analysis using colon tissue from 252 IBD patients to determine genetic effects on gene expression and …
Enhancing ulcerative colitis treatment with traditional Chinese medicine
Publication Year: 2024 Source: World J Clin Cases PMID: 39464320
No Abstract
Outcomes of treatment cessation after switching to subcutaneous vedolizumab treatment in inflammatory bowel diseases
Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 39464507 DOI: 10.1177/17562848241290636
BACKGROUND: The usability of subcutaneous vedolizumab (s.c. VDZ) treatment in inflammatory bowel diseases (IBD; ulcerative colitis (UC), Crohn's disease (CD)) has been proven via clinical trials while real-world data collection is ongoing. OBJECTIVES: Our study evaluates the effectiveness, safety, patients' preferences, and psychological factors associated with s.c. VDZ treatment, after …
Interventions for Adjunctive Care in Patients With Inflammatory Bowel Disease and Permanent Ileostomy: A Systematic Review
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 39464622
No Abstract
Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8(+) T cells
Publication Year: 2024 Source: Front Immunol PMID: 39464882 DOI: 10.3389/fimmu.2024.1465175
INTRODUCTION: The maintenance of intestinal homeostasis depends on a complex interaction between the immune system, intestinal epithelial barrier, and microbiota. Alteration in one of these components could lead to the development of inflammatory bowel diseases (IBD). Variants within the autophagy gene ATG16L1 have been implicated in susceptibility and severity of …
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