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Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors
Publication Year: 2024 Source: J Inflamm Res PMID: 38544813
No Abstract
Subcutaneous Vedolizumab Treatment in a Real-World Inflammatory Bowel Disease Cohort Switched From Intravenous Vedolizumab: Eighteen-Month Prospective Follow-up Study
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 38544907
No Abstract
Environmental Exposure to Trace Elements and Heavy Metals Preceding the Clinical Onset of Inflammatory Bowel Disease
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 38544908 DOI: 10.1093/crocol/otae018
BACKGROUND: The immune dysregulation underlying inflammatory bowel disease (IBD) can start years before the diagnosis, but the role of triggering factors and environmental exposures during this period is still uncertain. METHODS: This single-center case-control study included asymptomatic subjects with an incidental diagnosis of IBD during the colorectal cancer screening program. …
The impact of age, disease severity, and BMI on bone health and growth in children and young people with Crohn's disease
Publication Year: 2024 Source: JPGN Rep PMID: 38545265 DOI: 10.1002/jpr3.12037
OBJECTIVES: The objective of this study was to explore the correlation between paediatric Crohn's disease (CD) characteristics, bone health and growth parameters at diagnosis and follow-up. METHODS: Retrospective data was collected for 47 children aged 4-16 who were newly diagnosed with CD between January 2018 and December 2019. Mean follow-up …
Oral pathobiont Klebsiella chaperon usher pili provide site-specific adaptation for the inflamed gut mucosa
Publication Year: 2024 Source: Gut Microbes PMID: 38545880 DOI: 10.1080/19490976.2024.2333463
The ectopic gut colonization by orally derived pathobionts has been implicated in the pathogenesis of various gastrointestinal diseases, including inflammatory bowel disease (IBD). For example, gut colonization by orally derived Klebsiella spp. has been linked to IBD in mice and humans. However, the mechanisms whereby oral pathobionts colonize extra-oral niches, …
Nonconventional Dysplasia is Frequently Associated With Goblet Cell Deficient and Serrated Variants of Colonic Adenocarcinoma in Inflammatory Bowel Disease
Publication Year: 2024 Source: Am J Surg Pathol PMID: 38546105 DOI: 10.1097/PAS.0000000000002217
Various subtypes of nonconventional dysplasia have been recently described in inflammatory bowel disease (IBD). We hypothesized that goblet cell deficient dysplasia and serrated dysplasia may be the primary precursor lesions for goblet cell deficient (GCDAC) and serrated (SAC) variants of colonic adenocarcinoma, respectively. Clinicopathologic features of 23 GCDAC and 10 …
Live Biotherapeutic Products for the Prevention of Recurrent Clostridioides difficile Infection
Publication Year: 2024 Source: Ann Pharmacother PMID: 38546138
No Abstract
Minimally Invasive Surgery for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Robotic Versus Laparoscopic Surgical Techniques
Publication Year: 2024 Source: J Crohns Colitis PMID: 38546219
No Abstract
Intestinal strictures in Crohn's disease: An update from 2023
Publication Year: 2024 Source: United European Gastroenterol J PMID: 38546434
No Abstract
Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease
Publication Year: 2024 Source: J Med Chem PMID: 38547240 DOI: 10.1021/acs.jmedchem.3c02304
Inflammatory bowel disease (IBD) is a multifactorial chronic inflammation of the intestine and has become a global public health concern. A farnesoid X receptor (FXR) was recently reported to play a key role in hepatic-intestinal circulation, intestinal metabolism, immunity, and microbial regulation, and thus, it becomes a promising therapeutic target …
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