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Marine sponge-derived alkaloid ameliorates DSS-induced IBD via inhibiting IL-6 expression through modulating JAK2-STAT3-SOCS3 pathway
Publication Year: 2024 Source: Int Immunopharmacol PMID: 38350353 DOI: 10.1016/j.intimp.2024.111576
Cyanogramide (AC14), a novel alkaloid, isolated from the fermentation broth of the marine-derived Actinoalloteichus cyanogriseus. However, the exact role of AC14 in inflammatory bowel disease (IBD) is poorly understood. Our results demonstrated that AC14 exhibited significant inhibition of IL-6 release in THP-1 cells and a "Caco-2/THP-1" coculture system after stimulation …
Evaluation of a Multimodal Stress Management and Comprehensive Lifestyle Modification Program on Quality of Life and Gastrointestinal Symptoms in Patients with Crohn's Disease: A Randomized Controlled Pilot Trial with 9-Month Follow-Up
Publication Year: 2024 Source: Digestion PMID: 38350430
No Abstract
A randomized controlled trial of a digital cognitive-behavioral therapy program (COMPASS) for managing depression and anxiety related to living with a long-term physical health condition
Publication Year: 2024 Source: Psychol Med PMID: 38350600
No Abstract
Author's reply: Assessing disease severity in inflammatory bowel disease - Can we reliably encompass the full disease burden?
Publication Year: 2024 Source: Dig Liver Dis PMID: 38350763
No Abstract
Very early onset inflammatory bowel diseases: Is it the time to share and define a histopathological reporting scheme?
Publication Year: 2024 Source: Dig Liver Dis PMID: 38350764
No Abstract
Dubosiella newyorkensis modulates immune tolerance in colitis via the L-lysine-activated AhR-IDO1-Kyn pathway
Publication Year: 2024 Source: Nat Commun PMID: 38351003
No Abstract
Role of Sam68 as an adaptor protein in inflammatory signaling
Publication Year: 2024 Source: Cell Mol Life Sci PMID: 38351330
No Abstract
Impact of trial attrition rates on treatment effect estimates in chronic inflammatory diseases: A meta-epidemiological study
Publication Year: 2024 Source: Res Synth Methods PMID: 38351627
No Abstract
Improved Outcomes Associated With Teduglutide Use in Patients With Both Short Bowel Syndrome and Crohn's Disease
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 38352117
No Abstract
Formylated Peptide Receptor-1-Mediated Gut Inflammation as a Therapeutic Target in Inflammatory Bowel Disease
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 38352118 DOI: 10.1093/crocol/otae003
BACKGROUND: Formylated peptide receptor (FPR)-1 is a G-coupled receptor that senses foreign bacterial and host-derived mitochondrial formylated peptides (FPs), leading to innate immune system activation. AIM: We sought to investigate the role of FPR1-mediated inflammation and its potential as a therapeutic target in inflammatory bowel disease (IBD). METHODS: We characterized …
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