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Metabolic regulation of the Th17/Treg balance in inflammatory bowel disease
Publication Year: 2024 Source: Pharmacol Res PMID: 38615874 DOI: 10.1016/j.phrs.2024.107184
Inflammatory bowel disease (IBD) is a long-lasting and inflammatory autoimmune condition affecting the gastrointestinal tract, impacting millions of individuals globally. The balance between T helper 17 (Th17) cells and regulatory T cells (Tregs) is pivotal in the pathogenesis and progression of IBD. This review summarizes the pivotal role of Th17/Treg …
Oral Administration of PLGA Nanoparticles to Deliver Antisense Oligonucleotides to Inflammatory Lesions in the Gastrointestinal Tract
Publication Year: 2024 Source: Biol Pharm Bull PMID: 38616115 DOI: 10.1248/bpb.b23-00769
In this study, we prepared antisense oligonucleotide (ASO)-encapsulated nanoparticles (NPs) with a suitable profile for oral administration for the treatment of inflammatory bowel disease (IBD). We chose a water-in-oil-in-water (w/o/w) method to prepare the NPs using poly(lactide-co-glycolide) as a matrix and Pluronic as a stabilizer. The obtained NPs had a …
Controversies in medical vs surgical management of ileocecal crohn's disease
Publication Year: 2024 Source: Dig Liver Dis PMID: 38616139
No Abstract
Oral Budesonide and low serum albumin levels at surgery are associated with a higher risk of postoperative intra-abdominal septic complications after primary ileocaecal resection for Crohn's disease: A retrospective analysis of 853 consecutive patients
Publication Year: 2024 Source: Dig Liver Dis PMID: 38616140 DOI: 10.1016/j.dld.2024.03.014
BACKGROUND AND AIMS: The terminal ileum is the most frequent site of Crohn's Disease (CD) that necessitates surgery. Of the postoperative complications (POCs) associated with ileocaecal resection for CD, intra-abdominal septic complications (IASCs) include anastomotic leak, abscesses, and entero-cutaneous fistula. We aimed to identify predictors of IASCs and severe POCs …
Endovascular repair of bilateral isolated common iliac artery aneurysms with unsuitable anatomy utilizing an aortic bifurcated unibody endograft and modified sandwich technique to preserve pelvic blood flow: a case series
Publication Year: 2024 Source: J Cardiothorac Surg PMID: 38616244 DOI: 10.1186/s13019-024-02674-2
Bilateral isolated common iliac artery aneurysms (CIAAs) are rare, and endovascular repair of CIAAs has emerged as an alternative to traditional open surgical repair. The primary goal of therapy is to exclude the aneurysm sac while maintaining perfusion of at least one internal iliac artery (IIA) to prevent pelvic ischemia. …
Application of clinical decision support tools for predicting outcomes with vedolizumab therapy in patients with inflammatory bowel disease: A KASID multicentre study
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38616380
No Abstract
Crohn's disease after surgery: Changes in post-operative management strategies over time and their impact on long-term re-operation rate-A retrospective multicentre real-world study
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38616417 DOI: 10.1111/apt.18001
BACKGROUND: Few data are available addressing the impact of post-operative management of Crohn's disease (CD) on long-term clinical course. AIM: To assess the evolution of post-operative management strategies over the last 40 years and their impact on the re-operation rate of CD. METHODS: We included 657 patients with CD who …
Exploring the Link Between Ankylosing Spondylitis and Inflammatory Bowel Disease: A Retrospective Cohort Study
Publication Year: 2024 Source: Isr Med Assoc J PMID: 38616667
BACKGROUND: Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are chronic conditions with overlapping pathogenic mechanisms. The genetic predisposition and inflammatory pathways common to both diseases suggest a syndemic relationship. While some evidence points to a connection between the two conditions, other reports do not support this link. OBJECTIVES: To …
Hidradenitis suppurativa as a potential risk factor of periodontitis: a multi-center, propensity-score-matched cohort study
Publication Year: 2024 Source: Int J Med Sci PMID: 38617008
No Abstract
First-trimester exposure to tofacitinib in ulcerative colitis: A case report of a healthy newborn and literature review
Publication Year: 2024 Source: Clin Case Rep PMID: 38617066
No Abstract
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