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Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications
Publication Year: 2024 Source: Front Immunol PMID: 38469291 DOI: 10.3389/fimmu.2024.1359540
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD), mainly categorized into Crohn's disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients' quality of life. IBD patients often experience comorbidities such as anxiety and depression, and the underlying mechanisms and treatment strategies remain areas of …
Corrigendum: The role of cholesterol and mitochondrial bioenergetics in activation of the inflammasome in IBD
Publication Year: 2024 Source: Front Immunol PMID: 38469317 DOI: 10.3389/fimmu.2024.1384162
[This corrects the article DOI: 10.3389/fimmu.2022.1028953.].
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis
Publication Year: 2024 Source: Am J Physiol Gastrointest Liver Physiol PMID: 38469632
No Abstract
Anaerostipes hadrus, a butyrate-producing bacterium capable of metabolizing 5-fluorouracil
Publication Year: 2024 Source: mSphere PMID: 38470044
No Abstract
Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut
Publication Year: 2024 Source: mBio PMID: 38470269 DOI: 10.1128/mbio.00078-24
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract. The etiology of IBD remains elusive, but the disease is suggested to arise from the interaction of environmental and genetic factors that trigger inadequate immune responses and inflammation in the intestine. The gut microbiome majorly contributes …
In vitro mucin degradation and paracellular permeability by fecal water from Crohn's disease patients
Publication Year: 2024 Source: Future Microbiol PMID: 38470403
No Abstract
Ginsenosides from Panax ginseng as potential therapeutic candidates for the treatment of inflammatory bowel disease
Publication Year: 2024 Source: Phytomedicine PMID: 38471369 DOI: 10.1016/j.phymed.2024.155474
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the intestine, which significantly affects patients' quality of life. As a perennial plant with the homology of medicine and food, Panax ginseng is known for its substantial anti-inflammatory effects in various inflammatory disorders. Ginsenosides, the main bioactive compounds …
Tryptophan degradation as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases
Publication Year: 2024 Source: EBioMedicine PMID: 38471395 DOI: 10.1016/j.ebiom.2024.105056
BACKGROUND: Chronic inflammatory diseases (CIDs) are systems disorders that affect diverse organs including the intestine, joints and skin. The essential amino acid tryptophan (Trp) can be broken down to various bioactive derivatives important for immune regulation. Increased Trp catabolism has been observed in some CIDs, so we aimed to characterise …
Peripheral and intestinal T lymphocyte subsets in dogs with chronic inflammatory enteropathy
Publication Year: 2024 Source: J Vet Intern Med PMID: 38472110 DOI: 10.1111/jvim.17036
BACKGROUND: Dysregulated T lymphocyte response is thought to play a key role in chronic intestinal inflammation (CIE). OBJECTIVES: To evaluate the presence of changes in peripheral and intestinal T lymphocyte subsets and to describe potential immune and inflammatory biomarkers in dogs with CIE. ANIMALS: Sixteen healthy dogs and 26 dogs …
Association between body mass index and age of disease onset with clinical outcomes in paediatric-onset Crohn's Disease (CD): a UK nation-wide analyses using the NIHR-IBD BioResource
Publication Year: 2024 Source: Eur J Clin Nutr PMID: 38472359 DOI: 10.1038/s41430-024-01425-9
BACKGROUND: The evidence on the relationship between adiposity and disease outcomes in paediatric Crohn's disease (CD) is limited and lacks consensus. AIM: To investigate the relationship between (a) body mass index (BMI) and clinical CD outcomes (hospitalisation, surgery, disease behaviour, biologic use, extra-intestinal manifestations (EIMs)) and (b) the age of …
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