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Risk of colorectal cancer in patients with primary sclerosing cholangitis and concomitant inflammatory bowel disease compared with primary sclerosing cholangitis only
Publication Year: 2024 Source: Hepatol Res PMID: 38419394 DOI: 10.1111/hepr.14029
AIM: Primary sclerosing cholangitis (PSC) increases the risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients; however, there is a paucity of literature to suggest PSC alone as an independent risk factor for CRC. We aimed to determine if PSC is an independent risk factor for CRC in …
Transcutaneous fluorescence spectroscopy: development and characterization of a compact, portable, and fiber-optic sensor
Publication Year: 2024 Source: J Biomed Opt PMID: 38419754
No Abstract
Escherichia coli K88 activates NLRP3 inflammasome-mediated pyroptosis in vitro and in vivo
Publication Year: 2024 Source: Biochem Biophys Rep PMID: 38419757
No Abstract
No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study
Publication Year: 2024 Source: Front Genet PMID: 38419785 DOI: 10.3389/fgene.2024.1334473
Background: Although previous studies found that inflammatory bowel disease (IBD) and diverticular disease (DD) usually co-exist clinically, studies examining the relationship are spare. Aim: Our study aspires to investigate the causal correlation between the IBD [including ulcerative colitis (UC) and Crohn's disease (CD)] and DD using the Mendelian randomization (MR) …
Pneumatosis Intestinalis Manifesting as an Atypical Presentation of Crohn's Disease
Publication Year: 2024 Source: Cureus PMID: 38420063
No Abstract
Identification of platelet-related subtypes and diagnostic markers in pediatric Crohn's disease based on WGCNA and machine learning
Publication Year: 2024 Source: Front Immunol PMID: 38420127
No Abstract
ExpLOring the role of the intestinal MiCrobiome in InflammATory bowel disease-AssocIated SpONdylarthritis (LOCATION-IBD)
Publication Year: 2024 Source: Heliyon PMID: 38420375 DOI: 10.1016/j.heliyon.2024.e26571
BACKGROUND: Inflammatory Bowel Disease (IBD)-associated arthritis is a frequent and potentially debilitating complication of IBD, that can affect those with or without active intestinal disease, and is often difficult to treat. The microbiome is known to play a role in IBD development and has been shown to be associated with …
Design, synthesis, in vitro and in vivo biological evaluation of pterostilbene derivatives for anti-inflammation therapy
Publication Year: 2024 Source: J Enzyme Inhib Med Chem PMID: 38421003
No Abstract
The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease
Publication Year: 2024 Source: Hum Genet PMID: 38421405 DOI: 10.1007/s00439-024-02642-9
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor receptor (CSF1R). Analysis of genome-wide association studies (GWAS) indicates that dysregulation of macrophage differentiation and response to microorganisms contributes to susceptibility to chronic inflammatory bowel disease (IBD). Here, we analyzed transcriptomic variation in …
FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA
Publication Year: 2024 Source: Cell Mol Life Sci PMID: 38421448 DOI: 10.1007/s00018-024-05133-2
Macrophage polarization is closely related to inflammation development, yet how macrophages are polarized remains unclear. In our study, the number of M1 macrophages was markedly increased in Fam76b knockout U937 cells vs. wild-type U937 cells, and FAM76B expression was decreased in M1 macrophages induced from different sources of macrophages. Moreover, …
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