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Anchang Yuyang Decoction inhibits experimental colitis-related carcinogenesis by regulating PPAR signaling pathway and affecting metabolic homeostasis of host and microbiota
Publication Year: 2024 Source: J Ethnopharmacol PMID: 38428656 DOI: 10.1016/j.jep.2024.117995
ETHNOPHARMACOLOGICAL RELEVANCE: Inflammatory bowel disease (IBD) presents a risk of carcinogenesis, which escalates with the duration of IBD. Persistent histological inflammation is considered to be the driving factor of colitis carcinogenesis. Effective control of inflammation is helpful to prevent and treat colitis-related colorectal cancer (CAC). Anchang Yuyang Decoction (AYD), a …
Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota
Publication Year: 2024 Source: J Ethnopharmacol PMID: 38428658
No Abstract
White Paper: American Gastroenterological Association Position Statement: The Future of IBD Care in the United States-Removing Barriers and Embracing Opportunities
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 38428707 DOI: 10.1016/j.cgh.2024.01.050
Despite incredible growth in systems of care and rapidly expanding therapeutic options for people with inflammatory bowel disease, there are significant barriers that prevent patients from benefiting from these advances. These barriers include restrictions in the form of prior authorization, step therapy, and prescription drug coverage. Furthermore, inadequate use of …
Defining Endoscopic Remission in Crohn's Disease: MM-SES-CD and SES-CD Thresholds Associated With Low Risk of Disease Progression
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 38428709
No Abstract
Epithelial regulation of microbiota-immune cell dynamics
Publication Year: 2024 Source: Mucosal Immunol PMID: 38428738
No Abstract
Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study
Publication Year: 2024 Source: Sci Rep PMID: 38429331 DOI: 10.1038/s41598-024-55869-x
To investigate the association between T2DM and IBD by bidirectional two-sample Mendelian randomization (MR) to clarify the casual relationship. Independent genetic variants for T2DM and IBD were selected as instruments from published genome-wide association studies (GWAS), mainly in European ancestry. Instrumental variables (IVs) associated with T2DM and IBD were extracted …
Inflammatory bowel disease (IBD) patients with impaired quality of life on biologic therapy benefit from the support of an IBD nurse specialist: Results of a randomised controlled trial in Germany (IBD(BIO-ASSIST) study)
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38429885 DOI: 10.1111/apt.17926
BACKGROUND: IBD(BIO-ASSIST) was a randomised controlled trial assessing the efficacy of care provided by IBD nurse specialists in Germany in improving health-related quality of life (QoL) in IBD patients on biologic therapy. AIM: To evaluate patient-related outcomes and economic consequences associated with integrating IBD nurses into usual care. METHODS: We …
Retinoic acid-loaded liposomes induce human mucosal CD103(+) dendritic cells that inhibit Th17 cells and drive regulatory T-cell development in vitro
Publication Year: 2024 Source: Eur J Immunol PMID: 38430190 DOI: 10.1002/eji.202350839
The active vitamin A metabolite, all-trans-retinoic acid (RA), primes precursor dendritic cells (DCs) into a mucosal phenotype with tolerogenic properties characterized by the expression of integrin CD103. CD103(+) DCs can counteract pathogenic Th1 and Th17 in inflammatory bowel disease (IBD) or celiac disease (CD). Tolerogenic manipulation of DCs using nanoparticles …
Chronic gastrointestinal immune-related adverse events in patients exposed to immune checkpoint inhibitors
Publication Year: 2024 Source: Clin Res Hepatol Gastroenterol PMID: 38430989
No Abstract
Dynamic Prediction of Advanced Colorectal Neoplasia in Inflammatory Bowel Disease
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 38431223 DOI: 10.1016/j.cgh.2024.02.014
BACKGROUND & AIMS: Colonoscopic surveillance is recommended in patients with colonic inflammatory bowel disease (IBD) given their increased risk of colorectal cancer (CRC). We aimed to develop and validate a dynamic prediction model for the occurrence of advanced colorectal neoplasia (aCRN, including high-grade dysplasia and CRC) in IBD. METHODS: We …
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