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Colorectal Cancer Risk is a Family Affair
Publication Year: 2024 Source: Dis Colon Rectum PMID: 38603807 DOI: 10.1097/DCR.0000000000003369
No Abstract
Perianal disease: Updates and controversies in closing the gaps
Publication Year: 2024 Source: Semin Pediatr Surg PMID: 38603820
No Abstract
Has the time come for a systematic top-down approach in Crohn's disease?
Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 38604192
No Abstract
A women-focused matrix mentorship programme in gastroenterology
Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 38604193
No Abstract
Microbiota therapeutics for inflammatory bowel disease: the way forward
Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 38604201 DOI: 10.1016/S2468-1253(23)00441-7
Microbiota therapeutics that transplant faecal material from healthy donors to people with mild-to-moderate ulcerative colitis have shown the potential to induce remission in about 30% of participants in small, phase 2 clinical trials. Despite this substantial achievement, the field needs to leverage the insights gained from these trials and progress …
Gut-tropic T cells and extra-intestinal autoimmune diseases
Publication Year: 2024 Source: Autoimmun Rev PMID: 38604462 DOI: 10.1016/j.autrev.2024.103544
Gut-tropic T cells primarily originate from gut-associated lymphoid tissue (GALT), and gut-tropic integrins mediate the trafficking of the T cells to the gastrointestinal tract, where their interplay with local hormones dictates the residence of the immune cells in both normal and compromised gastrointestinal tissues. Targeting gut-tropic integrins is an effective …
Intestinal Inflammation and Extraintestinal Disease: Understanding Dynamic Risk
Publication Year: 2024 Source: Gastroenterology PMID: 38604541
No Abstract
Plasmids in the human gut reveal neutral dispersal and recombination that is overpowered by inflammatory diseases
Publication Year: 2024 Source: Nat Commun PMID: 38605009 DOI: 10.1038/s41467-024-47272-x
Plasmids are pivotal in driving bacterial evolution through horizontal gene transfer. Here, we investigated 3467 human gut microbiome samples across continents and disease states, analyzing 11,086 plasmids. Our analyses reveal that plasmid dispersal is predominantly stochastic, indicating neutral processes as the primary driver of their wide distribution. We find that …
The Effect of Inflammatory Bowel Disease and Irritable Bowel Syndrome on Pravastatin Oral Bioavailability: In vivo and in silico evaluation using bottom-up wbPBPK modeling
Publication Year: 2024 Source: AAPS PharmSciTech PMID: 38605192 DOI: 10.1208/s12249-024-02803-z
The common disorders irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) can modify the drugs' pharmacokinetics via their induced pathophysiological changes. This work aimed to investigate the impact of these two diseases on pravastatin oral bioavailability. Rat models for IBS and IBD were used to experimentally test the effects …
Impact of Obesity and Metabolic Syndrome on IBD Outcomes
Publication Year: 2024 Source: Dig Dis Sci PMID: 38864929 DOI: 10.1007/s10620-024-08504-8
PURPOSE OF REVIEW: The recent surge in inflammatory bowel disease (IBD) cases has paralleled a significant rise in obesity and metabolic comorbidities rates. In this article, we explore the potential influence of obesity and associated metabolic comorbidities on disease progression, complications, treatment response, surgical outcomes, health economics, and the potential …
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