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Gut Dysbiosis Drives Inflammatory Bowel Disease Through the CCL4L2-VSIR Axis in Glycogen Storage Disease
Publication Year: 2024 Source: Adv Sci (Weinh) PMID: 38889269 DOI: 10.1002/advs.202309471
Patients with glycogen storage disease type Ib (GSD-Ib) frequently have inflammatory bowel disease (IBD). however, the underlying etiology remains unclear. Herein, this study finds that digestive symptoms are commonly observed in patients with GSD-Ib, presenting as single or multiple scattered deep round ulcers, inflammatory pseudo-polyps, obstructions, and strictures, which differ …
High prevalence of vitamin D deficiency in Taiwanese patients with inflammatory bowel disease
Publication Year: 2024 Source: Sci Rep PMID: 38890510 DOI: 10.1038/s41598-024-64930-8
Vitamin D deficiency is common in patients with inflammatory bowel disease (IBD). In this study, we aimed to evaluate the prevalence and risk factors of vitamin D deficiency in a Taiwanese IBD cohort. Vitamin D levels were checked in adult patients with IBD who were treated at Changhua Christian Hospital, …
Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease
Publication Year: 2024 Source: BMC Pediatr PMID: 38890589
No Abstract
Inflammation accelerating intestinal fibrosis: from mechanism to clinic
Publication Year: 2024 Source: Eur J Med Res PMID: 38890719 DOI: 10.1186/s40001-024-01932-2
Intestinal fibrosis is a prevalent complication of IBD that that can frequently be triggered by prolonged inflammation. Fibrosis in the gut can cause a number of issues, which continue as an ongoing challenge to healthcare systems worldwide. The primary causes of intestinal fibrosis are soluble molecules, G protein-coupled receptors, epithelial-to-mesenchymal …
Stable Dietary Ora-Curcumin Formulation Protects from Experimental Colitis and Colorectal Cancer
Publication Year: 2024 Source: Cells PMID: 38891089 DOI: 10.3390/cells13110957
Inflammatory bowel disease (IBD) is a chronic gut disorder that also elevates the risk of colorectal cancer (CRC). The global incidence and severity of IBD are rising, yet existing therapies often lead to severe side effects. Curcumin offers potent anti-inflammatory and chemotherapeutic properties. However, its clinical translation is hindered by …
Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway
Publication Year: 2024 Source: Cells PMID: 38891118
No Abstract
Genetic Variation in Natural and Induced Antibody Responses in Layer Chickens
Publication Year: 2024 Source: Animals (Basel) PMID: 38891669 DOI: 10.3390/ani14111623
Selection of livestock for disease resistance is challenging due to the difficulty in obtaining reliable phenotypes. Antibodies are immunological molecules that provide direct and indirect defenses against infection and link the activities of both the innate and adaptive compartments of the immune system. As a result, antibodies have been used …
Findings and Prognosis in 149 Horses with Histological Changes Compatible with Inflammatory Bowel Disease
Publication Year: 2024 Source: Animals (Basel) PMID: 38891685 DOI: 10.3390/ani14111638
Inflammatory bowel disease (IBD) is a chronic disease characterized by different cell infiltrates in the intestine. The aims of this study were to report the clinical and clinicopathological findings in horses with histological changes compatible with IBD in the duodenum. Further, the clinical progression of IBD and survival were investigated. …
Serum D-Lactate Concentrations in Dogs with Inflammatory Bowel Disease
Publication Year: 2024 Source: Animals (Basel) PMID: 38891751 DOI: 10.3390/ani14111704
The D-enantiomer of lactic acid (D-lactate) is normally produced from bacterial fermentation in the gastrointestinal tract in mammals. In humans, increased D-lactate concentrations are related to gastrointestinal disease, including short bowel syndrome and malabsorptive syndrome. Similarly, increased D-lactate concentrations have been described in calves affected by diarrhea, in cats with …
Ace Deficiency Induces Intestinal Inflammation in Zebrafish
Publication Year: 2024 Source: Int J Mol Sci PMID: 38891786 DOI: 10.3390/ijms25115598
Inflammatory bowel disease (IBD) is a nonspecific chronic inflammatory disease resulting from an immune disorder in the intestine that is prone to relapse and incurable. The understanding of the pathogenesis of IBD remains unclear. In this study, we found that ace (angiotensin-converting enzyme), expressed abundantly in the intestine, plays an …
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