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High Rates of Seroprotection to Hepatitis B After a Hepatitis B Challenge Dose in Previously Vaccinated Patients with Inflammatory Bowel Disease on Immunosuppressive Therapy
Publication Year: 2024 Source: Dig Dis Sci PMID: 38907090 DOI: 10.1007/s10620-024-08527-1
BACKGROUND: Healthy populations have high rates of sustained vaccine-induced seroprotection to hepatitis B virus, but previous studies in immunosuppressed patients with inflammatory bowel disease (IBD) have shown suboptimal seroprotection rates. A challenge dose of hepatitis B vaccine (HepB) is recommended in previously vaccinated individuals who are seronegative to elicit an …
Correction: "Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease"
Publication Year: 2024 Source: Microbiome PMID: 38907319
No Abstract
Dysplasia Detected in Patients With Serrated Epithelial Change Is Frequently Associated With an Invisible or Flat Endoscopic Appearance, Nonconventional Dysplastic Features, and Advanced Neoplasia
Publication Year: 2024 Source: Am J Surg Pathol PMID: 38907614 DOI: 10.1097/PAS.0000000000002271
The significance of serrated epithelial change (SEC), defined as endoscopically invisible hyperplastic polyp (HP)-like mucosal change identified in patients with inflammatory bowel disease (IBD), remains unclear. Although some studies reported an increased risk of synchronous and/or metachronous colorectal neoplasia in patients with SEC, including advanced neoplasia (high-grade dysplasia or colorectal …
The role of chest X-rays when screening for latent tuberculosis infection in patients with inflammatory bowel disease before starting biologic treatment
Publication Year: 2024 Source: Scand J Gastroenterol PMID: 38907722 DOI: 10.1080/00365521.2024.2368248
BACKGROUND: Guidelines generally recommend a combination of immunological assays and chest X-ray imaging (CXR) when screening for latent tuberculosis infection (LTBI) prior to biologic treatment in inflammatory bowel disease (IBD). OBJECTIVE: To investigate whether CXR identify patients with suspected LTBI/TB who were not identified with QuantiFERON tests (QFT) when screening …
Alleviating Pyroptosis of Intestinal Epithelial Cells to Restore Mucosal Integrity in Ulcerative Colitis by Targeting Delivery of 4-Octyl-Itaconate
Publication Year: 2024 Source: ACS Nano PMID: 38907726
No Abstract
An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells
Publication Year: 2024 Source: Cell Rep PMID: 38907996
No Abstract
Recommendations for Broadening Eligibility Criteria in Inflammatory Bowel Disease Clinical Trials
Publication Year: 2024 Source: J Crohns Colitis PMID: 38908002 DOI: 10.1093/ecco-jcc/jjae097
BACKGROUND: Clinical trial recruitment for patients with inflammatory bowel disease (IBD) has become more challenging over time. We aimed to develop recommendations for broadening IBD clinical trial eligibility to improve the inclusion of a more representative patient population in a more efficient timeline. METHODS: We applied the RAND/UCLA Appropriateness Method …
Histopathological characterization and grading of chronic enterocolitis in Sulawesi crested macaques (Macaca nigra)
Publication Year: 2024 Source: J Comp Pathol PMID: 38908093 DOI: 10.1016/j.jcpa.2024.05.002
Sulawesi crested macaques (Macaca nigra) (SCMs) are critically endangered and frequently suffer from chronic intestinal disease in captivity. Often, despite routine diagnostic investigations and confirmation of intestinal inflammation, an aetiology cannot be identified, leading to a non-specific categorization as chronic enterocolitis rather than an aetiological diagnosis. This study evaluates the …
Inhibition of the STAT3-EPHX2 axis promotes regression of ulcerative colitis by treatment with novel porphyrin derivative
Publication Year: 2024 Source: Bioorg Chem PMID: 38908128
No Abstract
Restoring immune balance with Tregitopes: A new approach to treating immunological disorders
Publication Year: 2024 Source: Biomed Pharmacother PMID: 38908205
No Abstract
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