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Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents

Publication Year: 2024 Source: RSC Med Chem PMID: 38911165 DOI: 10.1039/d4md00053f

Inflammation is the body's response to defence against infection or injury, and is associated with the progression of many diseases, such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA). LCA, a dibenzylbutane lignan extracted from the roots of traditional medicinal plant Litsea cubeba (Lour.) Pers., has demonstrated promising anti-inflammatory …

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Publication Year: 2024 Source: Engineering (Beijing) PMID: 38911180 DOI: 10.1016/j.eng.2023.06.007

Intestinal homeostasis is maintained by specialized host cells and the gut microbiota. Wnt/beta-catenin signaling is essential for gastrointestinal development and homeostasis, and its dysregulation has been implicated in inflammation and colorectal cancer. Axin1 negatively regulates activated Wnt/beta-catenin signaling, but little is known regarding its role in regulating host-microbial interactions in …

Causal effects of circulating glutamine on colitis, IBD, and digestive system cancers: a Mendelian randomisation study

Publication Year: 2024 Source: J Cancer PMID: 38911392 DOI: 10.7150/jca.96085

Backgrounds: There is growing evidence linking glutamine levels to the risk of gastrointestinal diseases, yet the presence of a causal relationship remains uncertain. In this study, we employed a Mendelian randomization (MR) approach to investigate potential causal associations between glutamine and colitis, inflammatory bowel disease (IBD), and digestive tumors. Methods: …

Sarcopenia as a Preoperative Risk Stratification Tool among Older Adults with Inflammatory Bowel Disease

Publication Year: 2024 Source: Adv Geriatr Med Res PMID: 38911683 DOI: 10.20900/agmr20240003

Sarcopenia, defined as a loss of muscle mass and function, is a physiologic factor that has been implicated as a predictor of adverse postoperative outcomes in many older adult populations. However, data related to sarcopenia in older adults with inflammatory bowel disease (IBD) remain limited. Older adults with IBD are …

X-linked Inhibitor of Apoptosis (XIAP) Deficiency Complicated by Hemophagocytic Lymphohistiocytosis on Immunotherapy Leading to Acute Respiratory Distress Syndrome and Multiorgan Failure Secondary to Opportunistic Infections

Publication Year: 2024 Source: Cureus PMID: 38912075 DOI: 10.7759/cureus.62703

X-linked inhibitor of apoptosis (XIAP) deficiency is a rare primary immunodeficiency with a broad spectrum of clinical manifestations, including susceptibility to hemophagocytic lymphohistiocytosis (HLH), inflammatory bowel disease (IBD), hypogammaglobulinemia, and severe infections. We present a case of a 39-year-old male with a past medical history of XIAP deficiency complicated by …

Multimodal dynamic ultrasound approach as predictor of response in patients with Crohn's disease treated with ustekinumab

Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 38912296

No Abstract

The hospitalization burden of inflammatory bowel disease in a southwestern highland region of China: a territory-wide study from 2015 to 2020

Publication Year: 2024 Source: Front Med (Lausanne) PMID: 38912335 DOI: 10.3389/fmed.2024.1410714

BACKGROUND: Yunnan, a southwest highland and newly industrialized region of China, has an unknown hospitalization burden of inflammatory bowel disease (IBD). The study was conducted to explore territorial hospitalization burden of IBD. METHODS: The formatted medical records of patients with IBD were collected from a territory-wide database in Yunnan Province, …

Posterior Reversible Encephalopathy Syndrome After Infliximab Infusion for Fistulizing Crohn's Disease

Publication Year: 2024 Source: ACG Case Rep J PMID: 38912372

No Abstract

Granulomatous Salpingo-oophoritis Secondary to Crohn's Disease

Publication Year: 2024 Source: ACG Case Rep J PMID: 38912374

No Abstract

Use of Systemic Steroids for Inflammatory Bowel Disease Can Increase Intraocular Pressure

Publication Year: 2024 Source: Gastro Hep Adv PMID: 38912386

No Abstract

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