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IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy
Publication Year: 2024 Source: Front Immunol PMID: 38686385
No Abstract
Identifying serum metabolite biomarkers for autoimmune diseases: a two-sample mendelian randomization and meta-analysis
Publication Year: 2024 Source: Front Immunol PMID: 38686387 DOI: 10.3389/fimmu.2024.1300457
BACKGROUND: Extensive evidence suggests a link between alterations in serum metabolite composition and various autoimmune diseases (ADs). Nevertheless, the causal relationship underlying these correlations and their potential utility as dependable biomarkers for early AD detection remain uncertain. OBJECTIVE: The objective of this study was to employ a two-sample Mendelian randomization …
Novel Isoalantolactone-Based Derivatives as Potent NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization
Publication Year: 2024 Source: J Med Chem PMID: 38686671
No Abstract
Sacroiliitis in inflammatory bowel disease on abdominal computed tomography: prevalence, misses, and associated factors
Publication Year: 2024 Source: Scand J Rheumatol PMID: 38686835 DOI: 10.1080/03009742.2024.2337453
OBJECTIVE: To evaluate the prevalence and rate of a missed diagnosis of sacroiliitis on abdominal computed tomography (CT) in patients with inflammatory bowel disease (IBD). Factors associated with sacroiliitis were also assessed. METHOD: This retrospective study included 210 patients with IBD (mean age 31.1 years) who underwent abdominal CT. Based …
How Did It Get So Difficult to Care for Patients With Inflammatory Bowel Disease?
Publication Year: 2024 Source: Am J Gastroenterol PMID: 38686921
No Abstract
Sacroiliitis in inflammatory bowel disease
Publication Year: 2024 Source: Curr Opin Rheumatol PMID: 38687285 DOI: 10.1097/BOR.0000000000001017
PURPOSE OF REVIEW: This review summarizes the recent evidence regarding the epidemiology of inflammatory bowel disease (IBD) associated sacroiliitis, including the prevalence, pathogenesis, role of imaging, and therapeutic challenges. RECENT FINDINGS: Sacroiliitis is an underappreciated musculoskeletal manifestation of IBD, a chronic inflammatory condition of the gut affecting the younger population. …
Discovery of a New Anti-Inflammatory Agent from Anemoside B4 Derivatives and Its Therapeutic Effect on Colitis by Targeting Pyruvate Carboxylase
Publication Year: 2024 Source: J Med Chem PMID: 38687956 DOI: 10.1021/acs.jmedchem.4c00222
Anemoside B4 (AB4), a triterpenoidal saponin from Pulsatilla chinensis, shows significant anti-inflammatory activity, and may be used for treating inflammatory bowel disease (IBD). Nevertheless, its application is limited due to its high molecular weight and pronounced water solubility. To discover new effective agents for treating IBD, we synthesized 28 AB4 …
The chemical composition, protective effect of Rheum officinale leaf juice and its mechanism against dextran sulfate sodium-induced ulcerative colitis
Publication Year: 2024 Source: Phytomedicine PMID: 38688143
No Abstract
Risk of cancer in patients with bile acid diarrhoea: a Danish nationwide matched cohort study
Publication Year: 2024 Source: BMJ Open Gastroenterol PMID: 38688717
No Abstract
TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
Publication Year: 2024 Source: Exp Mol Med PMID: 38689088
No Abstract
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