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Bugs, TNF-alpha and IBD: more fuel for the fire
Publication Year: 2002 Source: Can J Gastroenterol PMID: 11875598 DOI: 10.1155/2002/834086
Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease in children. The aim of this study was to determine the characteristics and outcomes of children with PSC who were listed for liver transplantation (LT). Children who underwent transplantation for PSC according to the Studies of Pediatric Liver Transplantation (SPLIT) …
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
Publication Year: 2002 Source: Am J Hum Genet PMID: 11875755 DOI: 10.1086/339432
BACKGROUND & AIMS: Prophylactic treatment of mice with CpG motifs of bacterial DNA protects from experimental inflammatory bowel disease, at least partly via induction of inhibitory T-cells. The aim of this study was to elucidate whether these CpG-dependent protective effects require presence of bacterial flora suggesting antigen-specific regulatory activity. METHODS: …
Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity
Publication Year: 2002 Source: Gastroenterology PMID: 11878296 DOI: 10.1053/gast.2002.32124
BACKGROUND & AIMS: The mechanisms by which specific mutations in NOD2/CARD15 increase the risk for Crohn's disease (CD) are unclear. We identified proteins that interact with NOD2 and investigated them by expression, genetic, and functional analyses. METHODS: By using a yeast 2-hybrid screen of an intestinal epithelial library, we identified …
No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative Study
Publication Year: 2002 Source: J Neuroimmunol PMID: 11880164 DOI: 10.1016/s0165-5728(01)00493-3
An assumption-free algorithm has been applied to compute the probabilities of all possible identity-by-descent (IBD) configurations when the parents have not been genotyped. These probabilities can be used to determine the amount of information that a particular sibship will bring to a nonparametric linkage analysis. It is shown that the …
Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and healthy children
Publication Year: 2002 Source: Acta Paediatr PMID: 11883817 DOI: 10.1080/080352502753457932
In this report, we present evidence that the HLA class II DPB1 locus (or a locus with alleles in linkage disequilibrium with DPB1) contributes to Type I diabetes (IDDM) susceptibility in addition to the contribution of the HLA DR and DQ loci. The marker association segregation chi-square (MASC) method, which …
Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease
Publication Year: 2002 Source: Cytometry PMID: 12210145 DOI: 10.1002/cyto.10133
Mechanisms underlying the gastric toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) have been extensively investigated, whereas those leading to intestinal damage are not completely understood. Several hypotheses have been put forward on the pathophysiology of intestinal damage by NSAIDs: enhanced intestinal permeability, inhibition of cyclooxygenase (COX), enterohepatic recirculation, and formation of …
Platelets and anticoagulant capacity in patients with inflammatory bowel disease
Publication Year: 2002 Source: Pathophysiol Haemost Thromb PMID: 12214155 DOI: 10.1159/000065082
Trials of mycophenolate mofetil (MMF) in inflammatory bowel disease (IBD) suggest that it may be useful in patients intolerant of azathioprine. We examined the safety and efficacy of MMF in IBD patients intolerant of or unresponsive to azathioprine. Twelve patients [seven with Crohn's disease (CD); seven women; mean age 40 …
[Magnetic Resonance Imaging in diagnosis and follow-up of Crohn's Disease--Is conventional enteroclysis still necessary?]
Publication Year: 2002 Source: Z Gastroenterol PMID: 12215947 DOI: 10.1055/s-2002-33875
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha), may be involved in the pathogenesis of inflammatory bowel diseases (IBDs). The aim of this study was to evaluate the effect of TNF-alpha on the inflammatory activity of IBD. METHODS: TNF-alpha mRNA expression in intestinal mucosal biopsy specimens from IBD patients [ulcerative colitis (UC), n …
A method for computing identity by descent probabilities and quantitative trait loci mapping with dominant (AFLP) markers
Publication Year: 2002 Source: Genet Res PMID: 12220132 DOI: 10.1017/s0016672302005645
BACKGROUND: The chronicity of inflammatory bowel disease (IBD) and effects of medical and surgical treatments probably affect the daily lives of patients and may thus impair their health-related quality of life and psychological well-being. METHODS: Health-related quality of life and psychological distress were investigated in a population-based Swedish sample of …
Effects of chronic inflammatory bowel diseases on left ventricular structure and function: a study protocol
Publication Year: 2002 Source: BMC Public Health PMID: 12220482 DOI: 10.1186/1471-2458-2-19
The goals in developing animal models of inflammatory bowel disease (IBD) are to determine the underlying mechanisms and the action of currently available drugs and to evaluate the value of new therapeutic approaches. Because of the difficulty in determining the severity of colitis in living animals, it has been necessary …
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