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Analysis of the CC chemokine receptor 5 (CCR5) delta-32 polymorphism in inflammatory bowel disease
Publication Year: 2001 Source: Hum Genet PMID: 11354628 DOI: 10.1007/s004390100462
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Carrier rate of APC I1307K is not increased in inflammatory bowel disease patients of Ashkenazi Jewish origin
Publication Year: 2001 Source: Hum Genet PMID: 11354631 DOI: 10.1007/s004390100474
OBJECTIVE: An exact diagnosis of inflammatory bowel disease (IBD) and further subclassification may be difficult even after clinical, radiological and histological examinations. A correct subclassification is important for the success of both medical and surgical therapeutic strategies, but there is a dearth of information available on the frequency of changes …
Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis
Publication Year: 2001 Source: Int J Colorectal Dis PMID: 11355324 DOI: 10.1007/s003840100292
The relationship between a retroviral infection and the development of nonviral intracytoplasmic inclusion bodies was studied in a Boa constrictor model. Twelve juvenile age- and size-matched inclusion body disease (IBD)-negative boas were randomly divided into three groups. Each group was inoculated intraperitoneally with 1 ml of an IBD virus (IBDV)-infected …
Gene-environment interaction and affected sib pair linkage analysis
Publication Year: 2001 Source: Hum Hered PMID: 11359066 DOI: 10.1159/000053352
BACKGROUND: Recent studies have suggested that dietary fiber exerts a therapeutic effect on IBD patients. The aim of this study was to evaluate the effects of a dietary combination of germinated barley foodstuff (GBF), derived from the aleurone and scutellum fraction of germinated barley, plus Clostridium butyricum against dextran sulfate …
Psychological distress, social support, and disease activity in patients with inflammatory bowel disease
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11374685 DOI: 10.1111/j.1572-0241.2001.03800.x
Matrix metalloproteinase-9 (MMP-9) may play an important role in the development of inflammatory bowel disease (IBD). However, the cellular source of MMP-9 in the inflamed mucosa of IBD remains unclear. Here we report that MMP-9 mRNA is expressed in CaCO-2 cells, an intestinal epithelial cell line, and that its expression …
A prospective evaluation of health-related quality of life after ileal pouch anal anastomosis for ulcerative colitis
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11374686 DOI: 10.1111/j.1572-0241.2001.03801.x
Homeostasis in the colonic epithelium is achieved by a continuous cycle of proliferation and apoptosis, in which imbalances are associated with disease. Inflammatory bowel disease (IBD) and colon cancer are associated with either excessive or insufficient apoptosis of colonic epithelial cells, respectively. By using two colonic epithelial cell lines, HT29 …
Detection of Mycobacterium avium subspecies paratuberculosis in Crohn's diseased tissues by in situ hybridization
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11374694 DOI: 10.1111/j.1572-0241.2001.03751.x
Mucosal inflammation is characterized by increased expression of proinflammatory cytokines and chemoattractant chemokines, resulting in infiltration of immunocompetent cells. This study compared the degree of mucosal inflammation in human immunodeficiency virus type 1 (HIV-1)-infected gut mucosa with that in tissue samples from subjects with inflammatory bowel disease (IBD) and from …
Genetic analysis in Finnish families with inflammatory bowel disease supports linkage to chromosome 3p21
Publication Year: 2001 Source: Eur J Hum Genet PMID: 11378820 DOI: 10.1038/sj.ejhg.5200626
BACKGROUND & AIMS: Whether the bacterial flora contributes to the pathogenesis of inflammatory bowel disease (IBD) by increased penetration in mucus, increased adherence to epithelial cells, or invasion of the epithelium is unknown. We therefore studied the spatial distribution of bacteria in the mucosa of rectal biopsy specimens from patients …
Inflammatory bowel disease-like colitis in glycogen storage disease type 1b
Publication Year: 2001 Source: Inflamm Bowel Dis PMID: 11383585 DOI: 10.1097/00054725-200105000-00008
BACKGROUND & AIMS: Anti-Saccharomyces cerevisiae antibody (ASCA) is a serologic marker associated with Crohn's disease (CD). Although there is still discussion on its clinical value, several companies each promote their own ASCA assay to be used in the gastroenterologist's practice at considerable expense. The aim of this study was to …
An investigation of the association of the prothrombin G20210A gene mutation and inflammatory bowel disease: Factor II and IBD
Publication Year: 2001 Source: Inflamm Bowel Dis PMID: 11383586 DOI: 10.1097/00054725-200105000-00009
Inflammatory bowel disease (IBD) comprises two chronic, tissue-destructive, clinical entities: Crohn's disease (CD) and ulcerative colitis (UC), both immunologically based. Bowel symptoms are predominant, but extra-intestinal complications may occur, including involvement of the oral cavity. Oral involvement during IBD includes several types of lesions: the most common are aphthae; uncommon …
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