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Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12
Publication Year: 1999 Source: Genet Med PMID: 11256672 DOI: 10.1097/00125817-199907000-00005
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Differential behavior of coagulation factor XIII in patients with inflammatory bowel disease and in patients with giant cell arteritis
Publication Year: 1999 Source: Haemostasis PMID: 10844406 DOI: 10.1159/000022520
Anecdotally, people with inflammatory bowel disease (IBD) report that some foods make them feel better and some foods make them feel worse. This paper reports about the relationship between food habits and reactions to foods in people with IBD. A database was designed to incorporate the date of data collection, …
Toxic megacolon: diagnosis and treatment challenges
Publication Year: 1999 Source: AACN Clin Issues PMID: 10865533 DOI: 10.1097/00044067-199911000-00008
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Technetium leukocyte imaging in inflammatory bowel disease
Publication Year: 1999 Source: Curr Gastroenterol Rep PMID: 10980957 DOI: 10.1007/s11894-999-0042-2
Recent advances in the drug treatment of inflammatory bowel disease (IBD) have paralleled our understanding of the pathophysiology of ulcerative colitis and Crohn's disease. Several proinflammatory and immune-regulatory cytokines are upregulated in the mucosa of patients with IBD, and differences and similarities in the cytokine profiles of ulcerative colitis and …
Novel oral colon-specific drug delivery systems for pharmacotherapy of peptide and nonpeptide drugs
Publication Year: 1999 Source: Drugs Today (Barc) PMID: 12973398 DOI: 10.1358/dot.1999.35.7.548266
Recombinant human interleukin-11 (rhIL-11) reduces the clinical signs and histological lesions of inflammatory bowel disease (IBD) in transgenic rats expressing the human major histocompatability complex (MHC) class I allele, HLA-B27. To elucidate the pharmacogenomic effects of rhIL-11 in this model, we examined the global gene expression pattern in inflamed colonic …
Antibiotics in inflammatory bowel disease
Publication Year: 1999 Source: Drugs Today (Barc) PMID: 12973412 DOI: 10.1358/dot.1999.35.2.527965
In some clinical and research settings, it is often necessary to identify the true level of "identity by descent" (IBD) between two individuals. However, as the individuals become more distantly related, it is increasingly difficult to accurately calculate this value. Consequently, we have developed a computer program that uses genome-wide …
Feline inflammatory bowel disease: a review
Publication Year: 1999 Source: J Feline Med Surg PMID: 11919030 DOI: 10.1016/S1098-612X(99)90204-8
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Lessons for human inflammatory bowel disease from experimental models
Publication Year: 1999 Source: Curr Opin Gastroenterol PMID: 17023959 DOI: 10.1097/00001574-199907000-00002
The outcome of inflammatory diseases is likely to be dependent upon the relative balance of pro- versus anti-inflammatory cytokines. Control of this balance through the use of anti-cytokine monoclonal antibodies (mAbs) promises to be an effective means of disease therapy. The treatment of rheumatoid arthritis (RA) or inflammatory bowel disease …
Pathogenesis of inflammatory bowel disease
Publication Year: 1999 Source: Curr Opin Gastroenterol PMID: 17023960 DOI: 10.1097/00001574-199907000-00003
BACKGROUND: Many inflammatory bowel disease (IBD) studies have focused on Caucasian patients and little data exist on IBD in Hispanics living in the United States. AIM: The aim of our study was to compare IBD characteristics between Hispanic and Caucasian patients in the Harris County Hospital District (HCHD). METHODS: We …
Cytokine-based therapies in inflammatory bowel disease
Publication Year: 1999 Source: Curr Opin Gastroenterol PMID: 17023962 DOI: 10.1097/00001574-199907000-00005
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the intra- and extrahepatic bile ducts. An estimated 80% of patients in North America and Europe have coexistent inflammatory bowel disease (IBD). The underlying pathophysiology of PSC remains poorly understood. As a result, there …
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