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Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder
Publication Year: 1998 Source: Mol Psychiatry PMID: 9774776 DOI: 10.1038/sj.mp.4000457
The genes for tumour necrosis factor alpha (TNF alpha) and lymphotoxin alpha (LT alpha; TNF beta) are tandemly arranged in the central region of the MHC. They may, therefore, be of importance for the aetiology of MHC-associated diseases. The authors have prospectively studied the secretion of TNF alpha and LT …
Concentrations of the atherogenic Lp(a) are elevated in FH
Publication Year: 1998 Source: Eur J Hum Genet PMID: 9781014 DOI: 10.1038/sj.ejhg.5200152
BACKGROUND: The role of laparoscopic surgery in the treatment of various upper and lower gastrointestinal disorders is still under investigation. However, a variety of laparoscopic procedures may be applied in the treatment of inflammatory bowel disease (IBD). PATIENTS AND METHODS: We present our initial results of laparoscopic and laparoscopic-assisted management …
Prevalence and clinical significance of anti-lactoferrin autoantibodies in inflammatory bowel diseases and primary sclerosing cholangitis
Publication Year: 1998 Source: Adv Exp Med Biol PMID: 9781375 DOI: 10.1007/978-1-4757-9068-9_39
The aims of the study were to ascertain whether patients have similar a fertility rate to the background population in Leicestershire and whether they have a similar rate of congenital malformations compared to the background population in Leicestershire. Over 1400 patients were invided to participate with an overall response rate …
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism
Publication Year: 1998 Source: Infect Immun PMID: 9784517 DOI: 10.1128/IAI.66.11.5157-5166.1998
In this study we assessed the relationship of lipoprotein(a) [Lp(a)] with diabetes status and with measures of glucose and insulin in a population of Mexican Americans having a high prevalence of non-insulin-dependent diabetes mellitus (NIDDM). Because of enormous allelic diversity at LPA [the locus encoding the apo(a) protein] that directly …
Risk of colorectal cancer in relatives of patients with inflammatory bowel disease (Denmark)
Publication Year: 1998 Source: Cancer Causes Control PMID: 9794170 DOI: 10.1023/a:1008815600576
Not found
Effects of the anti-ICAM-1 monoclonal antibody on dextran sodium sulphate-induced colitis in rats
Publication Year: 1998 Source: J Gastroenterol Hepatol PMID: 9794195 DOI: 10.1111/j.1440-1746.1998.tb00766.x
Technetium-99m hexamethylpropylene amine oxime (HMPAO)-labeled leukocytes are well established for the investigation of inflammatory disease. Their kinetics and normal distribution are similar to those of indium-111-labeled leukocytes except for nonspecific activity in urine, kidneys, gall bladder, and bowel, which results from the elution of secondary 99mTc-labeled HMPAO complexes. The principal …
Atypical, cytoplasmic and perinuclear anti-neutrophil cytoplasmic antibodies in patients with inflammatory bowel disease
Publication Year: 1998 Source: J Gastroenterol Hepatol PMID: 9794196 DOI: 10.1111/j.1440-1746.1998.tb00767.x
Not found
Altered frequency of a promoter polymorphic allele of the kinin B1 receptor gene in inflammatory bowel disease
Publication Year: 1998 Source: Gastroenterology PMID: 9797354 DOI: 10.1016/s0016-5085(98)70071-x
Comment in Gastroenterology. 1998 Oct;115(4):1006-9. BACKGROUND & AIMS: Accurate serological assays are desirable for the diagnosis of inflammatory bowel disease (IBD) types in the pediatric age group. The aim of this study was to test the diagnostic accuracy of modified assays for perinuclear (p) antineutrophil cytoplasmic antibodies (ANCAs) and anti-Saccharomyces …
Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16
Publication Year: 1998 Source: Gastroenterology PMID: 9797358 DOI: 10.1016/s0016-5085(98)70074-5
The objective of this study was to determine the effect of human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) on inflammatory bowel disease (IBD). A retrospective survey of the medical records of St. Paul's Hospital and its AIDS-care physicians/gastroenterologists searching for patients with both HIV/AIDS and IBD was conducted. Of …
Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16
Publication Year: 1998 Source: Gastroenterology PMID: 9797359 DOI: 10.1016/s0016-5085(98)70075-7
Comment in Eur J Gastroenterol Hepatol. 1997 Apr;9(4):331-2. OBJECTIVE: To compare the methods used for diagnosis and the clinical features of non-specific inflammatory bowel disease (IBD) in the north and south of Europe. DESIGN: A prospective study over 2 years in 1991-3 at eight centres in the north and 12 …
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