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Semiparametric linkage analysis using pseudolikelihoods on neighbouring sets
Publication Year: 1998 Source: Ann Hum Genet PMID: 9924610 DOI: 10.1046/j.1469-1809.1998.6240323.x
ANCA were detected by indirect immunofluorescence in 34 out of 67 patients with ulcerative colitis (UC, 51%) and in 14 out of 35 patients with Crohn's disease (CD, 40%). All but one ANCA-positive sera produced a perinuclear pattern of fluorescence (P-ANCA) on ethanol-fixed neutrophils. On paraformaldehyde-fixed neutrophils 76% of P-ANCA-positive …
Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease
Publication Year: 1998 Source: Ann N Y Acad Sci PMID: 9928378 DOI: 10.1111/j.1749-6632.1998.tb11119.x
The cytokines IL-1 beta and IL-6 appear to be important in the pathogenesis of inflammatory bowel disease (IBD). Recently, a naturally occurring interleukin-1 receptor antagonist, designated IL-1ra, which inhibits IL-1 beta activity in vitro and in vivo has been described. The purpose of the present study was to assess the …
Sib mating designs for mapping quantitative trait loci
Publication Year: 1998 Source: Genetica PMID: 9949698 DOI: 10.1023/a:1003220609636
Inflammatory bowel disease (IBD) is chronic, incurable, and requires that affected patients cope with their condition on a constant basis. The purpose of this descriptive study was to predict the perceived health, functioning, and well-being among patients with IBD through the use and effectiveness of various coping methods. Forty-six patients …
Genetics of complex human diseases: genome screening, association studies and fine mapping
Publication Year: 1998 Source: Clin Exp Allergy PMID: 9988439 DOI: 10.1046/j.1365-2222.1998.028s5001.x
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Medical therapy of inflammatory bowel disease for the 21st century
Publication Year: 1998 Source: Eur J Surg Suppl PMID: 10029372 DOI: 10.1080/11024159850191517
Comment in Dig Dis Sci. 2010 Mar;55(3):869. Dig Dis Sci. 2010 Mar;55(3):867-8. The role of cytomegalovirus (CMV) infection in patients with inflammatory bowel disease (IBD) is controversial. Although CMV has been specifically associated with refractory disease, the strength and nature of this association have been a subject of debate. The …
Short-term regulation of endothelial Na(+)-K(+)-pump activity by cGMP: a 133Cs magnetic resonance study
Publication Year: 1998 Source: Mol Membr Biol PMID: 10087505 DOI: 10.3109/09687689709044320
Vasopressin and its receptors modulate several gut functions, but their role in intestinal inflammation is unknown. Our aims were to determine 1) the localization of V1b receptors in human and rodent colon, 2) the role of vasopressin and V1b receptors in experimental colitis using two approaches: V1b⁻(/)⁻ mice and a …
Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease
Publication Year: 1998 Source: Gut PMID: 10189845 DOI: 10.1136/gut.43.2.203
Inflammatory bowel disease (IBD) is thought to result from either an abnormal immunological response to enteric flora or a normal immunological response to a specific pathogen. No study to date has combined both factors. The present studies were carried out with an immunologically manipulated mouse model of IBD. Mice homozygous …
Genetic epidemiology in inflammatory bowel disease
Publication Year: 1998 Source: Dig Dis PMID: 10207221 DOI: 10.1159/000016891
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Genome-wide scanning in inflammatory bowel diseases
Publication Year: 1998 Source: Dig Dis PMID: 10207223 DOI: 10.1159/000016893
Inflammatory bowel disease (IBD) is often associated with anemia. Of 85 patients with IBD, 28 were anemic and had an inadequately low plasma erythropoietin (EPO) concentration. Three patients with a long-standing history of IBD and refractory chronic anemia (hemoglobin values < 10 g/dL, plasma EPO concentrations below 100 mU/mL) were …
Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease
Publication Year: 1998 Source: J Pathol PMID: 10209492 DOI: 10.1002/(SICI)1096-9896(199812)186:4<416::AID-PATH201>3.0.CO;2-U
OBJECTIVE: There is increasing knowledge of the pathophysiology behind inflammatory bowel disease (IBD) although the exact mechanism is far from fully understood. In the era of new technology, over the last years molecular approaches have shed light on the inflammatory mechanisms and their metabolic end products. This opens for a …
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